RT Journal Article T1 The Influence of Atrial Fibrillation on In-Hospital Mortality in People with Hospital-Acquired Pneumonia: An Observational, Sex-Stratified Study A1 Miguel Yanes, José María De A1 Jiménez García, Rodrigo A1 Miguel Díez, Javier De A1 Hernández Barrera, Valentín A1 Méndez Bailón, Manuel A1 Zamorano León, José Javier A1 López De Andrés, Ana Isabel AB (1) Background: The study aimed to analyze the influence of atrial fibrillation (AF) prior to hospital admission (“prevalent”) and new-onset AF diagnosed during hospital admission (“incident”) on in-hospital mortality (IHM) in women and men who developed hospital-acquired pneumonia (HAP) in Spain (2016–2019).(2) Methods: We used the Spanish Register of Specialized Care-Basic Minimum Database.(3) Results: We analyzed 38,814 cases of HAP (34.6% women; 13.5% ventilator-associated). Prevalent AF was coded in 19.9% (n = 7742), and incident AF in 5.5% (n = 2136) of HAP. Crude IHM was significantly higher for prevalent AF (34.22% vs. 27.35%, p < 0.001) and for incident AF (35.81% vs. 28.31%, p < 0.001) compared to no AF. After propensity score matching, IHM among women and men with prevalent AF was higher than among women and men with no AF (among women, 32.89% vs. 30.11%, p = 0.021; among men, 35.05% vs. 32.46%, p = 0.008). Similarly, IHM among women and men with incident AF was higher than among women and men with no AF (among women, 36.23% vs. 29.90%, p = 0.013; among men, 35.62% vs. 30.47%; p = 0.003). Sex was associated with a higher IHM only in people with incident AF (for female, OR = 1.21; 95% CI: 1.01–1.57).(4) Conclusions: Both prevalent and incident AF were associated with higher IHM in people who developed HAP. Female sex was associated with a higher IHM in incident AF. PB MPDI SN 2077-0383 YR 2022 FD 2022 LK https://hdl.handle.net/20.500.14352/71636 UL https://hdl.handle.net/20.500.14352/71636 LA eng NO Miguel Yanes, J. M., Jiménez García, R., Miguel Díez, J. et al. «The Influence of Atrial Fibrillation on In-Hospital Mortality in People with Hospital-Acquired Pneumonia: An Observational, Sex-Stratified Study». Journal of Clinical Medicine, vol. 11, n.o 5, febrero de 2022, p. 1179. DOI.org (Crossref), https://doi.org/10.3390/jcm11051179. NO Universidad Complutense de Madrid DS Docta Complutense RD 9 abr 2025