RT Patent
T1 Compounds derived from 3-Alkylamino-1H-indole acrylate, and the use thereof in the treatment of neurodegenerative diseases.
A1 León Martínez, Rafael
A1 Buendia Abaitua, Izaskun
A1 Navarro González De Mesa, Elisa
A1 Michalska Dziama, Patrycja
A1 Gameiro Ros, Isabel Marina
A1 López Vivo, Alicia
A1 Egea Máiquez, Francisco Javier
A1 García López, Manuela
A1 García García, Juan Antonio
AB The inventions relates to the methods for producing derivatives of 3-alkylamino-1-H indole acrylate (I) with transcription factor Nrf2-inducing activity, free radical scavenging activity and neuroprotective ability. The invention also relates to the use of derivatives according to the invention for the treatment of diseases, the pathogenesis of which involves oxidative stress,  or diseases involving the deregulation of the activity of phase II genes activated by the factor Nrf2 such as Alzheimer´s disease, Parkinson´s disease, Huntington´s disease, multiple sclerosis, ictus or amyotrophic lateral sclerosis.
YR 2015
FD 2015-10-15
LK https://hdl.handle.net/20.500.14352/100861
UL https://hdl.handle.net/20.500.14352/100861
LA eng
NO León Martínez R, Buendia Abaitua I, Navarro González De Mesa E, Michalska Dziama P, Gameiro Ros IM, López Vivo A, et al. Compounds derived from 3-Alkylamino-1H-indole acrylate, and the use thereof in the treatment of neurodegenerative diseases. 2015.
DS Docta Complutense
RD 22 abr 2025