RT Journal Article
T1 Bioactive Metabolites from the Endophytic Fungus Aspergillus sp. SPH2
A1 Morales Sánchez, Viridiana
A1 Díaz, Carmen E.
A1 Trujillo, Elena
A1 Olmeda García, Ángeles Sonia
A1 Valcarcel, Felix
A1 Muñoz, Rubén
A1 Andrés, María Fe
A1 González Coloma, Azucena
AB In the current study, an ethyl acetate extract from the endophytic fungus Aspergillus sp. SPH2 isolated from the stem parts of the endemic plant Bethencourtia palmensis was screened for its biocontrol properties against plant pathogens (Fusarium moniliforme, Alternaria alternata, and Botrytis cinerea), insect pests (Spodoptera littoralis, Myzus persicae, Rhopalosiphum padi), plant parasites (Meloidogyne javanica), and ticks (Hyalomma lusitanicum). SPH2 gave extracts with strong fungicidal and ixodicidal effects at different fermentation times. The bioguided isolation of these extracts gave compounds 1–3. Mellein (1) showed strong ixodicidal effects and was also fungicidal. This is the first report on the ixodicidal effects of 1. Neoaspergillic acid (2) showed potent antifungal effects. Compound 2 appeared during the exponential phase of the fungal growth while neohydroxyaspergillic acid (3) appeared during the stationary phase, suggesting that 2 is the biosynthetic precursor of 3. The mycotoxin ochratoxin A was not detected under the fermentation conditions used in this work. Therefore, SPH2 could be a potential biotechnological tool for the production of ixodicidal extracts rich in mellein.
PB MPDI
SN 2309-608X
YR 2021
FD 2021-02-02
LK https://hdl.handle.net/20.500.14352/7385
UL https://hdl.handle.net/20.500.14352/7385
LA eng
NO ERASMUS+
NO BIOCONTROL E TRAINING (BET)
DS Docta Complutense
RD 27 sept 2024