RT Journal Article
T1 Optical dark-field spectroscopy of single plasmonic nanoparticles for molecular biosciences
A1 Labrador Páez, Lucía
A1 Casasnovas-Melián, Alfredo
A1 Junquera González, María Elena
A1 Guerrero Martínez, Andrés
A1 Ahijado Guzmán, Rubén
AB An ideal sensor capable of quantifying analytes in minuscule sample volumes  represents a significant technological advancement. Plasmonic nanoparticles integrated with optical dark-field spectroscopy have reached this capability, demonstrating versatility and expanding applicability across in vitro and in vivo subjects. This review underscores the applicability of optical dark-field spectroscopy with single plasmonic nanoparticles to elucidate a wide range of biomolecular characteristics, including binding constants, molecular dynamics, distances, and forces, as well as recording cell communication signals. Perspectives highlight the potential for the development of implantable nanosensors for metabolite detection in animal models, illustrating the technique’s efficacy without the need for labeling molecules. In summary, this review aims to consolidate knowledge of this adaptable and robust technique for decoding molecular biological phenomena within the nano- and bio-scientific community.
PB The Royal Society of Chemistry
SN 2040-3364
SN 2040-3372
YR 2024
FD 2024
LK https://hdl.handle.net/20.500.14352/110607
UL https://hdl.handle.net/20.500.14352/110607
LA eng
NO Labrador-Páez L, Casasnovas-Melián A, Junquera E, Guerrero-Martínez A, Ahijado-Guzmán R. Optical dark-field spectroscopy of single plasmonic nanoparticles for molecular biosciences. Nanoscale 2024;16:19192–206. https://doi.org/10.1039/D4NR03055A
NO Ministerio de Ciencia, Innovación y Universidades
NO Comunidad de Madrid
DS Docta Complutense
RD 10 abr 2025