RT Journal Article T1 Proximal isovelocity surface area by single-beat three-dimensional color doppler echocardiography applied for tricuspid regurgitation quantification A1 De Agustín Loeches, José Alberto A1 Viliani, Dafne A1 Vieira, Catarina A1 Islas, Fabian A1 Marcos-Alberca, Pedro A1 Gomez de Diego, Jose Juan A1 Nunez-Gil, Ivan Javier A1 Almeria, Carlos A1 Rodrigo López, José Luis A1 Luaces Méndez, María A1 García Fernández, Miguel Ángel A1 Macaya Miguel, Carlos A1 Pérez De Isla, Leopoldo AB Background: The two-dimensional (2D) proximal isovelocity surface area (PISA) method has known technicallimitations, mainly the geometric assumptions of PISA shape required to calculate effective regurgitant orificearea (EROA). Recently developed single-beat real-time three-dimensional (3D) color Doppler imaging allowsthe direct measurement of PISA without geometric assumptions and has already been validated for mitralregurgitation assessment. The aim of this study was to apply this novel method in patients with chronictricuspid regurgitation (TR).Methods: Ninety patients with chronic TR were enrolled. EROA and regurgitant volume (Rvol) were assessedusing transthoracic 2D and 3D PISA methods. Quantitative Doppler and 3D transthoracic planimetry of EROAwere used as reference methods.Results: Both EROA and Rvol assessed using the 3D PISA method had better correlations with the referencemethods than using conventional 2D PISA, particularly in the assessment of eccentric jets. On the basis of 3Dplanimetry–derived EROA, 35 patients had severe TR (EROA $ 0.4 cm2). Among these 35 patients, 25.7%(n = 9) were underestimated as having nonsevere TR (EROA # 0.4 cm2) using the 2D PISA method. In contrast,the 3D PISA method had 94.3% agreement (33 of 35) with 3D planimetry in classifying severe TR. Goodintraobserver and interobserver agreement for 3D PISA measurements was observed, with intraclasscorrelation coefficients of 0.92 and 0.88 respectively.Conclusions: TR quantification using PISA by single-beat real-time 3D color Doppler echocardiography isfeasible in the clinical setting and more accurate than the conventional 2D PISA method. (J Am Soc Echocardiogr 2013;26:1063-72.) PB Elsevier SN 0894-7317 YR 2013 FD 2013 LK https://hdl.handle.net/20.500.14352/131331 UL https://hdl.handle.net/20.500.14352/131331 LA eng NO de Agustin, J. A., Viliani, D., Vieira, C., Islas, F., Marcos-Alberca, P., Gomez de Diego, J. J., Nuñez-Gil, I. J., Almeria, C., Rodrigo, J. L., Luaces, M., Garcia-Fernandez, M. A., Macaya, C., & Perez de Isla, L. (2013). Proximal isovelocity surface area by single-beat three-dimensional color Doppler echocardiography applied for tricuspid regurgitation quantification. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 26(9), 1063–1072. https://doi.org/10.1016/j.echo.2013.06.006 DS Docta Complutense RD 2 abr 2026