RT Journal Article
T1 Tramadol effects on physical performance and sustained attention during a 20-min indoor cycling time-trial: a randomised controlled trial
A1 Holgado, Darías
A1 Zandonai, Thomas
A1 Zabala, Mikel
A1 Hopker, James
A1 Perakakis, Pantelis
A1 Luque-Casado, Antonio
A1 Ciria, Luis
A1 Guerra-Hernandez, Eduardo
A1 Sanabria, Daniel
AB ObjectivesTo investigate the effect of tramadol on performance during a 20-min cycling time-trial (Experiment 1), and to test whether sustained attention would be impaired during cycling after tramadol intake (Experiment 2).DesignRandomized, double-blind, placebo controlled trial.MethodsIn Experiment 1, participants completed a cycling time-trial, 120-min after they ingested either tramadol or placebo. In Experiment 2, participants performed a visual oddball task during the time-trial. Electroencephalography measures (EEG) were recorded throughout the session.ResultsIn Experiment 1, average time-trial power output was higher in the tramadol vs. placebo condition (tramadol: 220 W vs. placebo: 209 W; p < 0.01). In Experiment 2, no differences between conditions were observed in the average power output (tramadol: 234 W vs. placebo: 230 W; p > 0.05). No behavioural differences were found between conditions in the oddball task. Crucially, the time frequency analysis in Experiment 2 revealed an overall lower target-locked power in the beta-band (p < 0.01), and higher alpha suppression (p < 0.01) in the tramadol vs. placebo condition. At baseline, EEG power spectrum was higher under tramadol than under placebo in Experiment 1 while the reverse was true for Experiment 2.ConclusionsTramadol improved cycling power output in Experiment 1, but not in Experiment 2, which may be due to the simultaneous performance of a cognitive task. Interestingly enough, the EEG data in Experiment 2 pointed to an impact of tramadol on stimulus processing related to sustained attention.
PB Elsevier
SN 1440-2440
YR 2018
FD 2018
LK https://hdl.handle.net/20.500.14352/100319
UL https://hdl.handle.net/20.500.14352/100319
LA eng
NO Darías Holgado, Thomas Zandonai, Mikel Zabala, James Hopker, Pandelis Perakakis, Antonio Luque-Casado, Luis Ciria, Eduardo Guerra-Hernandez, Daniel Sanabria, Tramadol effects on physical performance and sustained attention during a 20-min indoor cycling time-trial: A randomised controlled trial, Journal of Science and Medicine in Sport, Volume 21, Issue 7, 2018, Pages 654-660, ISSN 1440-2440, https://doi.org/10.1016/j.jsams.2017.10.032
NO World Anti-doping Agency
NO Ministerio de Economía y Competitividad (España)
NO Ministerio de Educación, Cultura y Deporte (España)
DS Docta Complutense
RD 7 abr 2025