RT Journal Article
T1 Retinal Macroglial Responses in Health and Disease
A1 Hoz Montañana, María Rosa De
A1 Rojas López, María Blanca
A1 Ramírez Sebastián, Ana Isabel
A1 Salazar Corral, Juan José
A1 Gallego Collado, Beatriz Isabel
A1 Triviño Casado, Alberto
A1 Ramírez Sebastián, José Manuel
AB Due to their permanent and close proximity to neurons, glial cells perform essential tasks for the normal physiology of the retina. Astrocytes andM¨uller cells (retinal macroglia) provide physical support to neurons and supplement them with several metabolites and growth factors.Macroglia are involved in maintaining the homeostasis of extracellular ions and neurotransmitters, are essential for information processing in neural circuits, participate in retinal glucose metabolism and in removing metabolic waste products, regulate local blood flow, induce the blood-retinal barrier (BRB), play fundamental roles in local immune response, and protect neurons from oxidative damage. In response to polyetiological insults, glia cells react with a process called reactive gliosis, seeking to maintain retinal homeostasis. When malfunctioning, macroglial cells can become primary pathogenic elements. A reactive gliosis has been described in different retinal pathologies, including age-related macular degeneration (AMD), diabetes, glaucoma, retinal detachment, or retinitis pigmentosa. A better understanding of the dual, neuroprotective, or cytotoxic effect of macroglial involvement in retinal pathologies would help in treating the physiopathology of these diseases.The extensive participation of the macroglia in retinal diseases points to these cells as innovative targets for new drug therapies.
PB Hindawi Publishing Corporation
SN 2314-6133
YR 2016
FD 2016-04-14
LK https://hdl.handle.net/20.500.14352/24693
UL https://hdl.handle.net/20.500.14352/24693
LA eng
NO Received 27 January 2016; Accepted 14 April 2016Copyright © 2016 Rosa de Hoz et al. This is an open access article distributed under the Creative Commons Attribution License,which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
NO Ministerio de Economía, Comercio y Empresa (España)
NO Instituto de Salud Carlos III
NO OFTARED
NO Fondo Europeo de Desarrollo Regional
DS Docta Complutense
RD 21 abr 2025