TY - JOUR AU - Torregrosa Muñumer, R. AU - Gómez, A. AU - Vara, E. AU - Kireev, R. AU - Barja De Quiroga Losada, Gustavo AU - Fernández-Tresguerres Hernández, Jesús Ángel AU - Gredilla Díaz, Ricardo PY - 2016 DO - 10.1007/s10522-015-9612-x SN - 1389-5729 UR - https://hdl.handle.net/20.500.14352/23349 T2 - Biogerontology AB - The senescence- accelerated mouse prone 8 (SAMP8) is a well- characterized animal model of senescence that shows early age- related neurodegeneration with impairment in learning and memory skills when compared with control senescence- resistant mice... LA - eng M2 - 325 PB - Springer Link KW - SAMP8 KW - Aging KW - Neurodegeneration KW - Mitochondrial DNA repair KW - 8-Hydroxydeoxyguanosine KW - Apoptosis KW - Inflammation TI - Reduced apurinic/apyrimidinic endonuclease 1 activity and increased DNA damage in mitochondria are related to enhanced apoptosis and inflammation in the brain of senescence- accelerated P8 mice (SAMP8) TY - journal article VL - 17 ER -