RT Journal Article
T1 Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary Syndrome
A1 Díez Villanueva, Pablo
A1 García Acuña, Jose María
A1 Raposeiras Roubin, Sergio
A1 Barrabés, Jose A.
A1 Cordero, Alberto
A1 Bardají, Alfredo
A1 Martínez-Sellés D Oliveira Soares, Manuel
A1 Marín, Francisco
A1 Ruiz Nodar, Juan M.
A1 Vicente Ibarra, Nuria
A1 Alonso Salinas, Gonzalo L.
A1 Cid Alvárez, Belén
A1 Abu Assi, Emad
A1 Formiga, Frances
A1 Núñez, Julio
A1 Núñez, Eduardo
A1 Ariza Solé, Albert
A1 Sanchis, Juan
AB Few studies have addressed to date the interaction between sex and diabetes mellitus (DM) in the prognosis of elderly patients with non-ST-segment elevation acute coronary syndrome (NSTEACS). Our aim was to address the role of DM in the prognosis of non-selected elderly patients with NSTEACS according to sex. A retrospective analysis from 11 Spanish NSTEACS registries was conducted, including patients aged ≥70 years. The primary end point was one-year all-cause mortality. A total of 7211 patients were included, 2,770 (38.4%) were women, and 39.9% had DM. Compared with the men, the women were older (79.95 ± 5.75 vs. 78.45 ± 5.43 years, p < 0.001) and more often had a history of hypertension (77% vs. 83.1%, p < 0.01). Anemia and chronic kidney disease were both more common in women. On the other hand, they less frequently had a prior history of arteriosclerotic cardiovascular disease or comorbidities such as peripheral artery disease and chronic pulmonary disease. Women showed a worse clinical profile on admission, though an invasive approach and in-hospital revascularization were both more often performed in men (p < 0.001). At a one-year follow-up, 1090 patients (15%) had died, without a difference between sexes. Male sex was an independent predictor of mortality (HR = 1.15, 95% CI 1.01 to 1.32, p = 0.035), and there was a significant interaction between sex and DM (p = 0.002). DM was strongly associated with mortality in women (HR: 1.45, 95% CI = 1.18–1.78; p < 0.001), but not in men (HR: 0.98, 95% CI = 0.84–1.14; p = 0.787). In conclusion, DM is associated with mortality in older women with NSTEACS, but not in men.
PB MPDI
SN 2077-0383
YR 2021
FD 2021-09-26
LK https://hdl.handle.net/20.500.14352/4796
UL https://hdl.handle.net/20.500.14352/4796
LA eng
NO Instituto de Salud Carlos III (ISCIII)/MINECO
DS Docta Complutense
RD 9 abr 2025