RT Journal Article T1 Salivary biomarkers in burning mouth syndrome: A systematicreview and meta-analysis A1 Fernández Agra, María A1 González Serrano, José A1 Pedro Herráez, Miguel de A1 Virto Ruiz, Leire A1 Caponio, Vito Carlo Alberto A1 Ibáñez Prieto, Elena A1 Hernández Vallejo, Gonzalo A1 López-Pintor Muñoz, Rosa María AB The objective of this systematic review was to evaluate which salivary biomarkers are altered in patients with burning mouth syndrome (BMS) compared to a control group (CG). A comprehensive literature search was conducted in four databases. Case– control studies evaluating salivary biomarkers in BMS patients were included. Risk of bias was assessed using the Newcastle-Ottawa tool. RevMan was used for metaanalysis. Seventeen studies were selected. The included studies collected 54 different biomarkers. Of these biomarkers, only three (cortisol, α-amylase, and dehydroepiandrosterone) were analyzed in three or more studies. Dehydroepiandrosterone obtained contradictory results among the studies. However, cortisol and α-amylase levels were found to be higher in BMS patients. Cortisol was the only biomarker which could be included for meta-analysis. Cortisol levels were significantly higher in the BMS group compared to the CG (Mean Difference = 0.39; 95% CI [0.14–0.65]; p = 0.003). In conclusion, different studies investigated salivary biomarkers in patients with BMS compared to a CG, with controversial results. Meta-analysis, confirmed by trial-sequential analysis, showed how cortisol levels were significantly higher in BMS. Cortisol emerges as an interesting salivary biomarker in BMS, but future properly designed studies are needed to evaluate its role in diagnosis and/or response to treatment. PB Wiley SN 1601-0825 YR 2022 FD 2022-09-22 LK https://hdl.handle.net/20.500.14352/72124 UL https://hdl.handle.net/20.500.14352/72124 LA eng NO CRUE-CSIC (Acuerdos Transformativos 2022) DS Docta Complutense RD 7 may 2024