RT Journal Article
T1 Clinical comparison of the effects of isoflurane or propofol anaesthesia on mean arterial blood pressure and ventilation in dogs undergoing orthopaedic surgery receiving epidural anaesthesia
A1 Canfrán Arrabe, Susana
A1 Álvarez Gómez De Segura, Ignacio
A1 Cediel Algovia, Rafael
A1 Bustamante Domínguez, Rocío
A1 Aguado Domínguez, Delia
AB The aim of this study was to compare the effects on mean arterial pressure (MAP) and ventilation of propofol total IV anaesthesia (TIVA) and isoflurane as anaesthetic maintenance in healthy dogs undergoing orthopaedic surgery, with epidural anaesthesia. Dogs were premedicated IM with dexmedetomidine (4 μg/kg) and methadone (0.3 mg/kg), induced with IV propofol (0.65–5 mg/kg) and randomly assigned to be maintained with isoflurane (group I) or propofol (group P). Isoflurane end-tidal concentration (EtISO) and propofol infusion rate were adjusted during the surgery to maintain a suitable anaesthetic depth. All dogs received bupivacaine (1 mg/kg) and morphine (0.1 mg/kg) in the lumbosacral epidural space (total volume 0.2 mL/kg). MAP was recorded every 5 min during the procedure. Statistical analysis was performed using parametric (Student's t test) and nonparametric (Mann–Whitney U-test, chi-square) tests, as appropriate. Anaesthetic maintenance in groups I and P was accomplished by providing a mean EtISO of 1.12 ± 0.15% and a mean propofol infusion rate of 15.0 ± 4.7 mg/kg/h, respectively. MAP was significantly higher in group P than in group I (92 ± 17 mmHg versus 78 ± 10 mmHg; P = 0.021). Eleven dogs in group P and two dogs in group I reached an EtCO2 > 7.3 kPa, requiring mechanical ventilation (P = 0.001). In combination with epidural anaesthesia, propofol TIVA improved MAP and is a suitable alternative to isoflurane in orthopaedic surgery of the hind limb in healthy dogs. Nevertheless, since it was associated with increased respiratory depression, mechanical ventilation should be available.
PB Elsevier
SN 1090-0233
YR 2018
FD 2018-03
LK https://hdl.handle.net/20.500.14352/101708
UL https://hdl.handle.net/20.500.14352/101708
LA eng
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 1 sept 2024