RT Journal Article
T1 Development, Spanish normative data, and validation of a social cognition battery in prodromal Alzheimer’s disease and multiple sclerosis
A1 Delgado Álvarez, Alfonso
A1 Pytel, Vanesa
A1 Delgado-Alonso, Cristina
A1 Olbrich-Guzmán, Carmen María
A1 Cortés-Martínez, Ana
A1 Moreno-Ramos, Teresa
A1 Montero-Escribano, Paloma
A1 Matías-Guiu Guía, Jorge
A1 Matias-Guiu, Jordi A
AB The assessment of social cognition changes may be challenging, especially in the earliest stages of some neurodegenerative diseases. Our objective was to validate a social cognition battery from a multidomain perspective. In this regard, we aimed to adapt several tests, collect normative data, and validate them in prodromal Alzheimer’s disease (AD) and multiple sclerosis (MS). Methdos: A total of 92 healthy controls, 25 prodromal AD, and 39 MS patients were enrolled. Age-, gender-, and education-matched control groups were created for comparisons. Social cognition battery was composed of an emotion-labeling task developed from FACES database, the Story-based Empathy test (SET), the Faux Pas test, and the Interpersonal Reactivity Index. Patients were also evaluated with a comprehensive cognitive battery to evaluate the other cognitive domains. Automatic linear modeling was used to predict each social cognition test’s performance using the neuropsychological tests examining other cognitive domains. Results: The reliability of the battery was moderate-high. Significant intergroup differences were found with medium-large effect sizes. Moderate correlations were found between social cognition battery and neuropsychological tests. The emotion labeling task and SET showed moderate correlations with age and education, and age, respectively. Regression-based norms were created considering the relevant demographic variables. Linear regression models including other neuropsychological tests explained between 7.7% and 68.8% of the variance of the social cognition tests performance. Conclusions: Our study provides a battery for the assessment of social cognition in prodromal AD and MS with Spanish normative data to improve the evaluation in clinical and research settings
PB Oxford University Press
SN 1873-5843
YR 2020
FD 2020-12-03
LK https://hdl.handle.net/20.500.14352/104087
UL https://hdl.handle.net/20.500.14352/104087
LA eng
DS Docta Complutense
RD 5 abr 2025