%0 Journal Article
%A Caballero, Esmeralda
%A Avendaño López, María Carmen
%A Menéndez Ramos, José Carlos
%T Synthesis of a seco analogue of ardeemin
%D 2000
%@ 03855414
%U https://hdl.handle.net/20.500.14352/133651
%X (1S,4S)-1-Indolylmethyl-4-methyl-2,4-dihydro-1H-pyrazino[2,1-b]-q uinazaline-3,6-dione, a seco analogue of ardeemin, was synthesized in six steps from L-tryptophan methyl ester via an N-protected 2,5-piperazinedione and using an aza-Wittig reaction for the preparation of the quinazoline system. The final acid-promoted deprotection required tuning of the reaction conditions in order to minimize a side reaction involving loss of the indolylmethyl side chain.
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