RT Journal Article
T1 Ocular Surface Disease in Patients under Topical Treatment for Glaucoma
A1 Pérez Bartolomé, Francisco
A1 Martínez De La Casa Fernández-Borrella, José María
A1 Arriola Villalobos, Pedro
A1 Fernández Pérez, Cristina
A1 Polo Llorens, Vicente
A1 García Feijoo, Julián
AB Purpose: To examine the relationship between ocular surface disease (OSD) and topical  antiglaucoma therapy. Methods: A total of 211 eyes of 211 patients with open-angle glaucoma or ocular hypertension on topical medication were recruited over 10 months. Controls were 51 eyes of 51 healthy age- and sex-matched volunteers. In each patient, we recorded the intraocular pressure-lowering eyedrops used, the number of medications used, and daily and cumulative preservative concentrations (PC). Main outcome measures were fluorescein corneal staining score (Oxford scale), lower tear meniscus height (LTMH) (spectral-domain optical coherence tomography), noninvasive tear film breakup time (NI-TBUT) (Oculus Keratograph 5M), and OSD symptom questionnaire index (OSDI).Results: Compared to controls, significantly higher OSDI (median [interquartile range] 10.24 [4.54-18.94] vs 2.5 [0-12.5]; p<0.001) and corneal staining (≥1: 64.93% vs 32.61%; p<0.001) scores were recorded in the medication group. The NI-TBUT and LTMH failed to vary between the groups (p>0.05). A higher daily PC was associated with a lower LTMH (R −0.142; p = 0.043). In the medication group, multivariate analysis identified correlations between benzalkonium chloride (BAK) (odds ratio [OR] 1.56) and BAK plus polyquaternium-containing drops (OR 5.09) or higher OSDI (OR 1.06) and abnormal corneal staining test results and between older age (mean ratio [MR] 1.05), longer treatment duration (MR 1.02), or corneal staining presence (MR 1.22) and a higher OSDI score.Conclusions: Ocular surface disease was more prevalent in the medication group. The main factors impacting OSD were drops with preservatives, longer treatment duration, and older age.
PB Wichtig Publishing
SN 1120-6721
YR 2018
FD 2018-01-10
LK https://hdl.handle.net/20.500.14352/11961
UL https://hdl.handle.net/20.500.14352/11961
LA eng
NO Pérez Bartolomé, F., Martínez De La Casa Fernández-Borrella, J. M., Arriola Villalobos, P. et al. «Ocular Surface Disease in Patients under Topical Treatment for Glaucoma». European Journal of Ophthalmology, vol. 27, n.o 6, noviembre de 2017, pp. 694-704. DOI.org (Crossref), https://doi.org/10.5301/ejo.5000977.
DS Docta Complutense
RD 20 jul 2024