RT Journal Article
T1 Virological Correlates of IgM–IgG Patterns of Response to SARS-CoV-2 Infection According to Targeted Antigens
A1 Barreiro, Pablo
A1 Candel González, Francisco Javier
A1 Sanz, Juan Carlos
A1 San Román Montero, Jesús
A1 del Mar Carretero, María
A1 Pérez Abeledo, Marta
A1 Ramos, Belén
A1 Viñuela Prieto, José Manuel
A1 Canora, Jesús
A1 Martínez Peromingo, Francisco Javier
A1 Zapatero, Antonio
AB The virological meaning of the different patterns of serology in COVID-19 has been little examined in clinical settings. Asymptomatic subjects with IgM-spike (S) and IgG-nucleocapsid (N) determinations by chemiluminescence were studied for SARS-CoV-2 shedding in respiratory secretions by transcription-mediated amplification (TMA). In subjects showing IgM-S positive and IgG-N negative, IgG-S was determined by lateral flow assay. A total of 712 individuals were tested: 30.0% presented IgM-S(+)/IgG-N(−), 25.8% had IgM-S(+)/IgG-N(+) and 44.2% had IgM-S(−)/IgG-N(+); the proportion with TMA(+) were comparable in these three groups: 12.1, 8.7 and 10.5%, respectively. In individuals with IgM-S(+)/IgG-N(−), IgG-S(+) was detected in 66.5%. The frequency of IgM-S(+)/IgG-S(−) in the total population was 10.0%, of whom 24.1% had TMA(+); the chances for TMA(+) in subjects with an IgM-S(+) alone pattern were 2.4%. Targeting of the same SARS-CoV-2 antigen seems to be better for the characterization of IgM/IgG patterns of response. IgM-S(+) alone reactivity is rare, and a small proportion is associated with viral shedding.
PB MDPI
SN 1999-4915
YR 2021
FD 2021-05-10
LK https://hdl.handle.net/20.500.14352/7403
UL https://hdl.handle.net/20.500.14352/7403
LA eng
NO This research was funded by the Council of Health, Community of Madrid.
NO Comunidad de Madrid
DS Docta Complutense
RD 20 jul 2024