RT Journal Article
T1 Ultrasound detection of externally induced microthrombi cloud formation: a theoretical study
A1 Guria, G. T.
A1 Herrero, Miguel A.
A1 Zlobina, K. E.
AB A mathematical model for the formation of microaggregates (microthrombi) of fibrin polymers in blood flow is considered. It is assumed that the former are induced by an external source (which may be of inflammatory or tumor nature) located in a tissue near the vessel. In either case, specific agents (e.g. cytokines) are emitted from that pathological site. Such substances permeate through the vessel wall to act as primary activators of blood coagulation. A mathematical criterion to describe the formation of an intravascular microthrombi cloud, which is interpreted as an early indicator of subsequent macroscopic thrombi formation is discussed. Such criteria are compared with available experimental detection tests for microthrombi cloud formation by means of ultrasound techniques. Moreover, a similarity-type relation is proposed that links the location of the unfolding microthrombi cloud and the place at which such primary activator reaches the vessel wall.
PB Springer
SN 0022-0833
YR 2010
FD 2010
LK https://hdl.handle.net/20.500.14352/42279
UL https://hdl.handle.net/20.500.14352/42279
LA eng
NO Spectromed (Moscow)
NO Russian Foundation of Basic Research
NO International Science and Technology Center
NO Universidad Complutense de Madrid
NO Spanish Research
DS Docta Complutense
RD 6 abr 2025