RT Journal Article
T1 Bispecific Antibody Format and the Organization of Immunological Synapses in T Cell-Redirecting Strategies for Cancer Immunotherapy
A1 Carrasco Padilla, Carlos
A1 Hernaiz Esteban, Alicia
A1 Álvarez Vallina, Luis
A1 Aguilar Sopeña, Óscar
A1 Roda Navarro, Pedro
AB T cell-redirecting strategies have emerged as effective cancer immunotherapy approaches. Bispecific antibodies (bsAbs) are designed to specifically recruit T cells to the tumor microenvironment and induce the assembly of the immunological synapse (IS) between T cells and cancer cells or antigen-presenting cells. The way that the quality of the IS might predict the effectiveness of T cell-redirecting strategies, including those mediated by bsAbs or by chimeric antigen receptors (CAR)-T cells, is currently under discussion. Here we review the organization of the canonical IS assembled during natural antigenic stimulation through the T cell receptor (TCR) and to what extent different bsAbs induce T cell activation, canonical IS organization, and effector function. Then, we discuss how the biochemical parameters of different formats of bsAbs affect the effectivity of generating an antigen-induced canonical IS. Finally, the quality of the IS assembled by bsAbs and monoclonal antibodies or CAR-T cells are compared, and strategies to improve bsAb-mediated T cell-redirecting strategies are discussed.
PB MDPI
SN 1999-4923
YR 2022
FD 2022-12-30
LK https://hdl.handle.net/20.500.14352/72336
UL https://hdl.handle.net/20.500.14352/72336
LA eng
NO Ministerio de Ciencia e Innovación (España)
NO Instituto de Salud Carlos III
NO Fundación CRIS del Cáncer
NO Asociación Española Contra el Cáncer
NO Fundación “La Caixa”
NO Fundación de Investigación Biomédica 12 de Octubre
DS Docta Complutense
RD 7 jul 2025