RT Journal Article
T1 Systematic review and modelling of Toxoplasma gondii seroprevalence in humans, Europe, 2000 to 2021
A1 Friesema, Ingrid HM
A1 Waap, Helga
A1 Swart, Arno
A1 Györke, Adriana
A1 Le Roux, Delphine
A1 Evangelista, Francisco MD
A1 Spano, Furio
A1 Schares, Gereon
A1 Deksne, Gunita
A1 Gargaté, Maria João
A1 Calero Bernal, Rafael
A1 Jokelainen, Pikka
A1 Seeber, Frank
A1 Sroka, Jacek
A1 Lundén, Anna
A1 van den Berg, Oda
A1 Jore, Solveig
A1 Wisselink, Henk J
A1 Dámek, Filip
A1 Vestergaard, Lasse S
A1 Opsteegh, Marieke
AB BACKGROUNDToxoplasma gondii is a zoonotic protozoan capable of infecting warm-blooded animal species and humans. Although toxoplasmosis presents mostly as mild or asymptomatic infection in immunocompetent individuals, in unborn children and people with weakened immune systems, the disease can be severe with ocular, neurological or multi-systemic manifestations and even death.AIMWe aimed to collate and analyse data on T. gondii seroprevalence in humans to model and compare age-dependent prevalence in geographic regions in Europe.METHODSA systematic review identified 1,822 scientific publications, from which seroprevalence data were extracted from 69 studies. Data were analysed using a Bayesian hierarchical model.RESULTSThe modelling of the seroprevalence indicated the highest incidence rates in eastern (50%) and western (48%) Europe, with the lowest estimates in northern Europe (18%) and the United Kingdom (UK) (18%). Eastern and western Europe were regions where T. gondii infections occurred earliest in life, with half of the population expected to be seropositive by the age of 44 and 47 years, respectively. In contrast, in northern Europe and the UK the modelled median time to infection exceeded 170 years.CONCLUSIONResults of the study provide a robust baseline for future epidemiological research on human T. gondii infections in Europe and may be useful to validate subsequent research, such as risk assessment studies
PB European Centre for Disease Prevention and Control
SN 1560-7917
YR 2025
FD 2025
LK https://hdl.handle.net/20.500.14352/124802
UL https://hdl.handle.net/20.500.14352/124802
LA eng
NO Friesema, I. H., Waap, H., Swart, A., Györke, A., Le Roux, D., Evangelista, F. M., Spano, F., Schares, G., Deksne, G., Gargaté, M. J., Calero-Bernal, R., Jokelainen, P., Seeber, F., Sroka, J., Lundén, A., van den Berg, O., Jore, S., Wisselink, H. J., Dámek, F., Vestergaard, L. S., … Opsteegh, M. (2025). Systematic review and modelling of Toxoplasma gondii seroprevalence in humans, Europe, 2000 to 2021. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 30(34), 2500069. https://doi.org/10.2807/1560-7917.ES.2025.30.34.2500069
NO Authors’ contributions: Ingrid HM Friesema: Conceptualisation, Data curation, Formal analysis, Methodology, Validation, Supervision, Writing – original draft, Writing – review & editing. Helga Waap: Writing – original draft, Writing – review & editing. Arno Swart: Formal analysis, Methodology, Validation, Writing – original draft, Writing – review & editing. Adriana Györke: Data curation, Formal analysis, Methodology, Writing – review & editing. Delphine Le Roux: Data curation, Formal analysis, Methodology, Writing – review & editing. Francisco Evangelista: Data curation, Formal analysis, Methodology, Writing – review & editing. Furio Spano: Data curation, Formal analysis, Methodology, Writing – review & editing. Gereon Schares: Data curation, Formal analysis, Methodology, Writing – review & editing. Gunita Deksne: Data curation, Formal analysis, Methodology, Writing – review & editing. Maria João Gargaté: Data curation, Formal analysis, Methodology, Writing – review & editing. Rafael Calero-Bernal: Data curation, Formal analysis, Methodology, Writing – review & editing. Pikka Jokelainen: Data curation, Formal analysis, Methodology, Supervision, Writing – review & editing. Frank Seeber: Data curation, Formal analysis, Methodology, Writing – review & editing. Jacek Sroka: Data curation, Formal analysis, Methodology, Writing – review & editing. Anna Lundén: Data curation, Formal analysis, Methodology, Writing – review & editing. Oda van den Berg: Data curation, Formal analysis, Methodology, Writing – review & editing. Solveig Jore: Data curation, Formal analysis, Methodology, Writing – review & editing. Henk J Wisselink: Data curation, Formal analysisMethodology, Writing – review & editing. Filip Dámek: Data curation, Formal analysis, Methodology, Writing – review & editing. Lasse S Vestergaard: Data curation, Formal analysis, Methodology, Writing – review & editing. Marieke Opsteegh: Conceptualisation, Data curation, Formal analysis, Methodology, Validation, Supervision, Writing – original draft, Writing – review & editing
DS Docta Complutense
RD 24 ene 2026