RT Conference Proceedings
T1 Regulations of the neurotrophin receptro TrkB by visible light.
T2 Regulación del receptor de neurotrofinas TrkB por la luz visible.
A1 Sánchez Ramos, Celia
A1 Vega, J.A.
A1 del Valle, M.E.
A1 Langa Moraga, Antonio
A1 Álvarez Fernández-Balbuena, Antonio
A1 Benítez Del Castillo Sánchez, José Manuel
AB INTRODUCTION: Of all neurotrophins, brain-derived neurotrophic factor (BDNF) seems to show most actions on the retina. Thus, through the TrkB receptor, BDNF controls the remodeling of the neuronal structures of the eye in a cell-specific and expriment-dependent manner.PURPOSE: To examine variations in the BDNF receptor TrkB produced in response to prolonged exposure to circadian cycles of light.METHODS: We examined the eyes of experimental rabbits exposed for two years to circadian cycles of white light, blue light and white light lacking short wavelengths. For the trial the animals had been implanted with a transparent introcular lens (IOL) and a yellow Acrysof (ALCON) IOL, one in each eye. Afeter sacrificing the animals, the retinal layer was dissected from the eye and processed for gene expression analysis using primers for TrkB.RESULTS: Prolonged light exposure resulted in elevated expression levels of the TrkB receptor as follow: 1.8 times in response to white light, 2.3 times in response to blue light, and 3.9 times in response to white light devoid of short wavelengths. In eyes implanted with a yellow IOL, a 4.2-fold increase in TrkB expression was observed.CONCLUSION; Exposure to light, irrespective of its characteristics, led to the incr3eased expression of the TrkB receptor. Expression levels were elevated most in response to white light devoid of short wavelengths. This finding suggets that the cells of the retinal layer expressing the receptor, which have yet to be indentified, are capable of reacting to the neuroprotective stimuli mediated by this molecule.
YR 2008
FD 2008-09-23
LK https://hdl.handle.net/20.500.14352/108394
UL https://hdl.handle.net/20.500.14352/108394
LA eng
DS Docta Complutense
RD 10 abr 2025