%0 Journal Article
%A Moreno-Quispe, Luz A
%A Serrano Valle, Julia
%A Virto Ruiz, Leire
%A Sanz Alonso, Mariano
%A Ramírez Sanz, Lucía
%A Fernández-Castro, Mónica
%A Hernández Vallejo, Gonzalo
%A López-Pintor Muñoz, Rosa María
%T Association of salivary inflammatory biomarkers with primary Sjögren’s syndrome
%D 2020
%@ 0904-2512
%U https://hdl.handle.net/20.500.14352/99868
%X Background: Primary Sjogren’s syndrome (pSS) is an autoimmune disease that leads to salivary and lacrimal gland dysfunction. The adaptive immune response associatedwith T helper-2 lymphocytes appears to be altered in these patients. Therefore, the objective of this study was to determine the salivary levels of IL-6, 5 and 4 in patientswith pSS when compared to a healthy control (HC) group. The secondary objectives were to study whether ILs levels in pSS patients were associated with salivary flow,patient-reported outcomes (PROMs) for xerostomia and oral health quality of life (OHIP-14), pSS classification criteria and presence of extraglandular manifestations.Methods: A case-control study was conducted in 36 patients with pSS and 35 HCs. Cytokine levels were measured using high-sensitivity multiplex map humanimmunoassays. Unstimulated and stimulated whole saliva were collected and patients filled out the questionnaires. The U-Mann-Whitney test, chi-squared and Spearmancorrelation test were used.Results: IL-6 was significantly higher in pSS patients than in HCs (p=0.0001). IL-6 was significantly higher in pSS patients with a positive salivary gland biopsy (p=0.04),whole stimulated saliva hyposalivation (p=0.02) and presence of musculoskeletal disorders (p=0.03). There was a non-significant positive correlation between IL-6 levelsand PROMs for xerostomia (r=0.31; p=0.06) and OHIP-14 (r=0.07; p=0.68) in pSS patients. Levels of IL4 and IL5 were not detected in both pSS and HCs patients.Conclusions: Salivary IL-6 levels were significantly associated with pSS patients and therefore, it is hypothesized that this biomarker may be useful in the diagnosis andfollow-up of this disease.
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