RT Journal Article
T1 Association of salivary inflammatory biomarkers with primary Sjögren’s syndrome
A1 Moreno Quispe, Luz A.
A1 Serrano Valle, Julia
A1 Virto Ruiz, Leire
A1 Sanz Alonso, Mariano
A1 Ramírez Sanz, Lucía
A1 Fernández Castro, Mónica
A1 Hernández Vallejo, Gonzalo
A1 López-Pintor Muñoz, Rosa María
AB Background: Primary Sjogren’s syndrome (pSS) is an autoimmune disease that leads to salivary and lacrimal gland dysfunction. The adaptive immune response associated with T helper-2 lymphocytes appears to be altered in these patients. Therefore, the objective of this study was to determine the salivary levels of IL-6, 5 and 4 in patients with pSS when compared to a healthy control (HC) group. The secondary objectives were to study whether ILs levels in pSS patients were associated with salivary flow, patient-reported outcomes (PROMs) for xerostomia and oral health quality of life (OHIP-14), pSS classification criteria and presence of extraglandular manifestations.Methods: A case-control study was conducted in 36 patients with pSS and 35 HCs. Cytokine levels were measured using high-sensitivity multiplex map human immunoassays. Unstimulated and stimulated whole saliva were collected and patients filled out the questionnaires. The U-Mann-Whitney test, chi-squared and Spearman correlation test were used.Results: IL-6 was significantly higher in pSS patients than in HCs (p=0.0001). IL-6 was significantly higher in pSS patients with a positive salivary gland biopsy (p=0.04), whole stimulated saliva hyposalivation (p=0.02) and presence of musculoskeletal disorders (p=0.03). There was a non-significant positive correlation between IL-6 levels and PROMs for xerostomia (r=0.31; p=0.06) and OHIP-14 (r=0.07; p=0.68) in pSS patients. Levels of IL4 and IL5 were not detected in both pSS and HCs patients.Conclusions: Salivary IL-6 levels were significantly associated with pSS patients and therefore, it is hypothesized that this biomarker may be useful in the diagnosis and follow-up of this disease.
PB Wiley
SN 0904-2512
YR 2020
FD 2020-06-04
LK https://hdl.handle.net/20.500.14352/99868
UL https://hdl.handle.net/20.500.14352/99868
LA eng
NO Moreno-Quispe LA, Serrano J, Virto L, et al. Association of salivary inflammatory biomarkers with primary Sjögren's syndrome. J Oral Pathol Med. 2020;00:1–8
NO National Council for Science, Technology and Technological Innovation
DS Docta Complutense
RD 9 abr 2025