RT Journal Article
T1 Alcohol and Hepatocellular Carcinoma: Adding Fuel to the Flame
A1 Ramadori, Pierluigi
A1 Cubero Palero, Francisco Javier
A1 Liedtke, Christian
A1 Trautwein, Christian
A1 Nevzorova, Yulia
AB Primary tumors of the liver represent the fifth most common type of cancer in the world and the third leading cause of cancer-related death. Case-control studies from different countries report that chronic ethanol consumption is associated with an approximately 2-fold increased odds ratio for hepatocellular carcinoma (HCC). Despite the substantial epidemiologic data in humans demonstrating that chronic alcohol consumption is a major risk factor for HCC development, the pathways causing alcohol-induced liver cancer are poorly understood. In this overview, we summarize the epidemiological evidence for the association between alcohol and liver cancer, review the genetic, oncogenic, and epigenetic factors that drive HCC development synergistically with ethanol intake and discuss the essential molecular and metabolic pathways involved in alcohol-induced liver tumorigenesis.
PB MDPI
SN 2072-6694
YR 2017
FD 2017-09-25
LK https://hdl.handle.net/20.500.14352/19162
UL https://hdl.handle.net/20.500.14352/19162
LA eng
NO Ministerio de Economía y Competitividad (MINECO)
NO Ministerio de Ciencia e Innovación (MICCIN)
NO German Research Foundation
DS Docta Complutense
RD 4 abr 2025