RT Journal Article
T1 Clinicopathological Relevance of Tumor Budding at the Invasive Tumor Front in Early-Stage Oral Tongue Squamous Cell Carcinoma: Histological and Immunohistochemical Analysis
A1 Espías Alonso, Samuel
A1 Alijo Serrano, Francisco
A1 Navarro Cuéllar, Ignacio
A1 López López, Ana
A1 Fernández Acosta, Diego
A1 González Moure, Borja
A1 Zamorano León, José Javier
A1 Navarro Cuéllar, Carlos
AB BackgroundTumor budding (TB) is characterized by isolated tumor cells or cell clusters at the invasive tumor front in squamous cell carcinoma (SCC) of the tongue.MethodsThis research (n = 61) aimed to analyze the diagnostic methodology of TB, the association between the tumoral features and TB, the immunohistochemical characteristics and their correlation with the TB index (TBI), assess the prognostic factors of TB in relation to cervical metastases and analyze disease-free survival (DFS) and overall survival (OS).ResultsA statistically significant association was found between TB and depth of invasion (DOI), perineural invasion, E-Cadherin expression, and Ki-67 index. Regarding cervical metastases, a statistically significant association was observed with DOI, perineural invasion, TBI, E-Cadherin expression, and Ki-67 index.ConclusionsTB correlates significantly with DOI and perineural invasion. Patients with a high TBI are associated with decreased E-cadherin expression and an increased Ki-67 index. TBI is an independent prognostic factor for the presence of cervical lymphatic metastases, and no association was found between the TBI and DFS or OS.
PB Wiley
SN 1043-3074
YR 2026
FD 2026-02-01
LK https://hdl.handle.net/20.500.14352/130113
UL https://hdl.handle.net/20.500.14352/130113
LA eng
NO Alonso, S. E., Serrano, F. A., Cuéllar, I. N., López, A. L., Acosta, D. F., Moure, B. G., León, J. Z., & Cuéllar, C. N. (2026). Clinicopathological Relevance of Tumor Budding at the Invasive Tumor Front in Early-Stage Oral Tongue Squamous Cell Carcinoma: Histological and Immunohistochemical Analysis. Head & neck, 48(2), 325–338. https://doi.org/10.1002/hed.28204
DS Docta Complutense
RD 20 ene 2026