RT Journal Article
T1 Maternal, Perinatal and Neonatal Outcomes of Triplet Pregnancies According to Chorionicity: A Systematic Review of the Literature and Meta-Analysis
A1 Bernal Claverol, Mireia
A1 Ruiz Minaya, Maria
A1 Aracil Moreno, Irene
A1 García Tizón, Santiago
A1 Pintado Recarte, María Del Pilar
A1 Álvarez Mon, Melchor
A1 Bravo Arribas, Coral
A1 Ortega, Miguel A.
A1 León Luis, Juan Antonio
AB Triplet pregnancies are rare events that affect approximately 93 in 100,000 deliveries in the world, especially due to the increased use of assisted reproductive techniques and older maternal age. Triplet pregnancies are associated with a higher risk of fetal and maternal morbidity and mortality compared to twins and singletons. Chorionicity has been proposed as a major determinant of perinatal and maternal outcomes in triplet pregnancies, although further evidence is needed to clarify the extent and real influence of this factor. Thus, the aim of this study was to conduct a systematic review of the literature and a meta-analysis of the maternal and perinatal outcomes of triplet pregnancies, evaluating how chorionicity may influence these results. A total of 46 studies with 43,653 triplet pregnancies and 128,145 live births were included. Among the main results of our study, we found a broad spectrum of fetal and maternal complications, especially in the group of monochorionic and dichorionic pregnancies. Risk of admission to NICU, respiratory distress, sepsis, necrotizing enterocolitis, perinatal and intrauterine mortality were all found to be higher in non-TCTA pregnancies than in TCTA pregnancies. To date, our meta-analysis includes the largest population sample and number of studies conducted in this field, evaluating a wide variety of outcome measures. The heterogeneity and retrospective design of the studies included in our research represent the main limitations of this review. More evidence is needed to fully assess outcome measures that could not be studied in this review due to scarcity of publications or insufficient sample size.
PB MDPI
SN 2077-0383
YR 2022
FD 2022-03-28
LK https://hdl.handle.net/20.500.14352/73380
UL https://hdl.handle.net/20.500.14352/73380
LA eng
NO Bernal Claverol, M., Ruiz Minaya, M., Aracil Moreno, I. et al. «Maternal, Perinatal and Neonatal Outcomes of Triplet Pregnancies According to Chorionicity: A Systematic Review of the Literature and Meta-Analysis». Journal of Clinical Medicine, vol. 11, n.o 7, marzo de 2022, p. 1871. DOI.org (Crossref), https://doi.org/10.3390/jcm11071871.
NO Unión Europea
NO Comunidad de Madrid
NO Instituto de Salud Carlos III
NO Halekulani S.L.
DS Docta Complutense
RD 21 abr 2025