RT Journal Article
T1 The right hippocampus leads the bilateral integration of gamma-parsed lateralized information
A1 Benito, N.
A1 Martin Velazquez, G.
A1 Makarova, V.A.
A1 Makarov Slizneva, Valeriy
A1 Herreras, O
AB It is unclear whether the two hippocampal lobes convey similar or different activities and how they cooperate. Spatial discrimination of electric fields in anesthetized rats allowed us to compare the pathway-specific field potentials corresponding to the gamma-paced CA3 output (CA1 Schaffer potentials) and CA3 somatic inhibition within and between sides. Bilateral excitatory Schaffer gamma waves are generally larger and lead from the right hemisphere with only moderate covariation of amplitude, and drive CA1 pyramidal units more strongly than unilateral waves. CA3 waves lock to the ipsilateral Schaffer potentials, although bilateral coherence was weak. Notably, Schaffer activity may run laterally, as seen after the disruption of the connecting pathways. Thus, asymmetric operations promote the entrainment of CA3-autonomous gamma oscillators bilaterally, synchronizing lateralized gamma strings to converge optimally on CA1 targets. The findings support the view that interhippocampal connections integrate different aspects of information that flow through the left and right lobes.
PB eLife Sciences Publications Ltd
SN 2050084X
YR 2016
FD 2016
LK https://hdl.handle.net/20.500.14352/24681
UL https://hdl.handle.net/20.500.14352/24681
LA eng
NO Ministerio de Economía y Competitividad (MINECO)
NO Ministerio de Ciencia e Innovación (MICINN)
NO Ministerio de Educación
NO Russian Science Foundation
NO Bioethics and Biosecurity Committee of the CSIC
NO Committee for Animal Research at the Cajal Institute
DS Docta Complutense
RD 30 abr 2024