RT Journal Article
T1 The influence of rigid gas permeable lens wear on the concentrations of dinucleotides in tears and the effect on dry eye signs and symptoms in keratoconus
A1 Carracedo Rodríguez, Juan Gonzalo
A1 González-Méijome, José Manuel
A1 Martín Gil, Alba
A1 Carballo Álvarez, Jesús
A1 Pintor, Jesús
AB Purpose: To evaluate the signs and symptoms of dry eye and dinucleotide secretion in tears of keratoconus patients (KC) and the potential effect of rigid gas permeable (RGP) contact lens wear.Methods: Twenty-three KC patients and forty control subjects were enrolled in this study. Signs of dry eye including tear volume, tear stability and corneal staining along with symptoms were assessed using the McMonnies questionnaire. Tears were collected using Schirmer strips, and dinucleotide concentrations in collected tears measured using high pressure liquid chromatography. Values obtained in KC and controls were compared. The effect of contact lens wear in KC was also assessed.Results: KC eyes showed a significantly lower tear volume compared to controls, shorter tear break up time (TBUT), higher corneal staining and higher McMonnies dry eye questionnaire scores (p < 0.05). When compared with non-wearers, KC contact lens wearers showed significantly higher symptoms, lower Schirmer and TBUT values (p < 0.05). Concentration of Ap4A (0.695 ± 0.304 μM vs. 0.185 ± 0.178 μM) and Ap5A (0.132 ± 0.128 μM vs. 0.045 ± 0.036 μM) were higher in KC compared to controls (p < 0.001) and only Ap4A was statistically higher in RGP wearers compared to non-wearers (0.794 ± 0.478 μM vs. 0.417 ± 0.313 μM) (p < 0.05).Conclusion: Signs and symptoms of dry eye as well as concentrations of Ap4A and Ap5A were markedly increased in KC patients compared to controls. Moreover, Ap4A and symptoms of dry eye were statistically higher in RGP wearers compared to non-wearers. This seems to indicate that factors such as RGP contact lens wear might exacerbate the clinical condition of dry eye.
PB Elsevier
SN 1367-0484
YR 2016
FD 2016-10
LK https://hdl.handle.net/20.500.14352/17685
UL https://hdl.handle.net/20.500.14352/17685
LA eng
NO Received 3 January 2016 ; Received in revised form 19 April 2016 ; Accepted 26 April 2016.
NO Ministerio de Ciencia e Innovación (MICINN)
NO RETICS (Redes Temáticas de Investigación Cooperativa en Salud)
DS Docta Complutense
RD 13 may 2025