RT Journal Article
T1 Silicon alleviates nonalcoholic steatohepatitis by reducing apoptosis in aged wistar rats fed a high-saturated fat, high-cholesterol diet
A1 Garcimartín Álvarez, Alba
A1 López-Oliva Muñoz, María Elvira
A1 Santos López, Jorge Arturo
A1 García Fernández, Rosa Ana
A1 Macho González, Adrián
A1 Bastida Codina, Sara
A1 Benedí González, Juana María
A1 Sánchez Muniz, Francisco José
AB Silicon included in a restructured meat (RM) matrix (Si-RM) as a functional ingredient has been demonstrated to be a potential bioactive antidiabetic compound. However, the jejunal and hepatic molecular mechanisms by which Si-RM exerts its cholesterol-lowering effects remain unclear. Male Wistar rats fed an RM included in a high-saturated-fat high-cholesterol diet (HSFHCD) combined with a low dose of streptozotocin plus nicotinamide injection were used as late-stage type 2 diabetes mellitus (T2DM) model. Si-RM was included into the HSFHCD as a functional food. An early-stage TD2M group fed a high-saturated-fat diet (HSFD) was taken as reference. Si-RM inhibited the hepatic and intestinal microsomal triglyceride transfer protein (MTP) reducing the apoB-containing lipoprotein assembly and cholesterol absorption. Upregulation of liver X receptor (LXRα/β) by Si-RM turned in a higher low-density lipoprotein receptor (LDLr) and ATP-binding cassette transporters (ABCG5/8, ABCA1) promoting jejunal cholesterol efflux and transintestinal cholesterol excretion (TICE), and facilitating partially reverse cholesterol transport (RCT). Si-RM decreased the jejunal absorptive area and improved mucosal barrier integrity. Consequently, plasma triglycerides and cholesterol levels decreased, as well as the formation of atherogenic lipoprotein particles. Si-RM mitigated the dyslipidemia associated with late-stage T2DM by Improving cholesterol homeostasis. Silicon could be used as an effective nutritional approach in diabetic dyslipidemia management.
PB ASN
SN 2304-8158
YR 2017
FD 2017
LK https://hdl.handle.net/20.500.14352/110030
UL https://hdl.handle.net/20.500.14352/110030
LA eng
NO Hernández-Martín, M., Garcimartín, A., Bocanegra, A., Redondo-Castillejo, R., Quevedo-Torremocha, C., Macho-González, A., García Fernández, R. A., Bastida, S., Benedí, J., Sánchez-Muniz, F. J., & López-Oliva, M. E. (2024). Silicon as a Functional Meat Ingredient Improves Jejunal and Hepatic Cholesterol Homeostasis in a Late-Stage Type 2 Diabetes Mellitus Rat Model. Foods, 13(12). https://doi.org/10.3390/FOODS13121794
NO Acknowledgments: We thank the Centro de Experimentacion Animal of the Alcal ´ a´ University, Madrid, Spain, for feeding and caring for the rats. The authors  responsibilities were as follows—AG, MEL-O, and FJS-M: designed the research; AG, MEL-O, JAS-L, AM-G, and RAG-F: conducted the research; AG, MEL-O, SB, and JB: analyzed the data; AG, MEL-O, SB, JB, and FJS-M: wrote the paper; FJS-M: had primary responsibility for the final content; and all authors: read and approved the final manuscriptExperimental design The study was approved by the Spanish Science and Technology Advisory Committee (project AGL2011-29644-C02-02) and by an ethics committee at the Universidad Complutense of Madrid (Spain).
NO Ministerio de Economía, Comercio y Empresa ( España)
NO Santander- Universidad Complutense de Madrid
DS Docta Complutense
RD 4 abr 2025