RT Journal Article
T1 Effect of therapeutic hypothermia on surfactant proteins, anti-inflammatory and pro-fibrotic mediators
A1 Autilio, Chiara
A1 Touqui, Lhousseine
A1 Foligno, Silvia
A1 Arroyo, Raquel
A1 Kingma, Paul S.
A1 Alonso Eugenio, Alejandro
A1 Pérez Gil, Jesús
A1 De Luca, Daniele
AB ObjectivesTo study the effect of hypothermia on surfactant proteins, anti-inflammatory and pro-fibrotic mediatorsDesignProspective, pragmatic study enrolling asphyxiated neonates without lung injury. Surfactant proteins (SP), Club cell secretory protein (CC-10), tumor growth factor-β1 (TGF-β1), human fibroblast growth factor-2 (hFGF) and anti-inflammatory interleukins (IL) were measured in broncho-alveolar lavage fluids obtained before, during and after hypothermia.ResultsTwelve neonates were studied. SP-A, -B, -C, -D and CC-10 levels were similar before, during and after hypothermia. IL-10, IL-13, IL-14 were inconsistently detected only in five out of twelve patients and not in all timepoints; TGF-β1 was always undetectable. hFGF decreased during hypothermia (pre = 92 [52–193.6], during = 19.4 [0–42.6], post = 31.8 [0–83] ng/mL, p = 0.026) with levels before hypothermia being significantly higher than those obtained during and after the treatment (post hoc p = 0.025).ConclusionsIn cooled neonates without any lung disorder, hypothermia is associated with lower hFGF but not with any changes in surfactant proteins or anti-inflammatory molecules.
PB Springer Nature
SN 0743-8346
YR 2025
FD 2025-04
LK https://hdl.handle.net/20.500.14352/124019
UL https://hdl.handle.net/20.500.14352/124019
LA eng
NO Autilio, C., Touqui, L., Foligno, S. et al. Effect of therapeutic hypothermia on surfactant proteins, anti-inflammatory and pro-fibrotic mediators. J Perinatol (2025). https://doi.org/10.1038/s41372-025-02285-2
DS Docta Complutense
RD 9 abr 2026