RT Journal Article
T1 Ultrasound-Mediated Cavitation-Enhanced Extravasation of Mesoporous Silica Nanoparticles for Controlled-Release Drug Delivery
A1 Paris, J.L.
A1 Mannaris, Christophoros
A1 Cabañas Criado, María Victoria
A1 Carlisle, Robert
A1 Manzano García, Miguel
A1 Vallet Regí, María Dulce Nombre
A1 Coussios, Constantin C.
AB Mesoporous silica nanoparticles have been reported as suitable drug carriers, but their successful delivery to target tissues following systemic administration remains a challenge. In the present work, ultrasound-induced inertial cavitation was evaluated as a mechanism to promote their extravasation in a flow-through tissue mimicking agarose phantom. Two different ultrasound frequencies, 0.5 or 1.6 MHz, with pressures in the range 0.5-4 MPa were used to drive cavitation activity which was detected in real time. The optimal ultrasound conditions identified were employed to deliver dye-loaded nanoparticles as a model for drug-loaded nanocarriers, with the level of extravasation evaluated by fluorescence microscopy. The same nanoparticles were then co-injected with submicrometric polymeric cavitation nuclei as a means to promote cavitation activity and decrease the required in-situ acoustic pressure required to attain extravasation. The overall cavitation energy and penetration of the combination was compared to mesoporous silica nanoparticles alone. The results of the present work suggest that combining mesoporous silica nanocarriers and submcrometric cavitation nuclei may help enhance the extravasation of the nanocarrier, thus enabling subsequent sustained drug release to happen from those particles already embedded in the tumour tissue.
PB Elsevier
SN 1385-8947
YR 2017
FD 2017-12-12
LK https://hdl.handle.net/20.500.14352/18311
UL https://hdl.handle.net/20.500.14352/18311
LA eng
NO RESEARCHER ID D-9318-2017 (Juan Luis Paris de la Fuente)ORCID 0000-0001-8950-283X (Juan Luis Paris de la Fuente)RESEARCHER ID G-8740-2015 (María Victoria Cabañas Criado)ORCID 0000-0002-4753-5665 (María Victoria Cabañas Criado)RESEARCHER ID K-3719-2014 (Miguel Manzano García)RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)ORCID 0000-0001-6238-6111 (Miguel Manzano García)
NO Unión Europea. H2020
NO Ministerio de Economía y Competitividad (MINECO)
NO UK’s Engineering and Physical Sciences Research Council
DS Docta Complutense
RD 10 abr 2025