RT Journal Article
T1 In Vitro and In Vivo Response of Zinc-Containing Mesoporous Bioactive Glasses in a Sheep Animal Model
A1 Jiménez Holguín, Javier
A1 Arcos Navarrete, Daniel
A1 Lozano Borregón, Daniel
A1 Sainz-Pardo Sanz, Melchor
A1 Ortega Medina, Luis
A1 Enciso, S
A1 Fernández Tomé, Blanca
A1 López Güemes, Idoia
A1 Sánchez Margallo, Francisco Miguel
A1 Casarrubios Molina, Laura
A1 Portolés Pérez, María Teresa
A1 Vallet Regí, María Dulce Nombre
AB Zinc-enriched mesoporous bioactive glasses (MBGs) are bioceramics with potential antibacterial and osteogenic properties. However, few assays have been performed to study these properties in animal models.In this study, MBGs enriched with up to 5% ZnO were synthesized, physicochemically characterized, and evaluated for their osteogenic activity both in vitro and in vivo.The ZnO MBGs showed excellent textural properties despite ZnO incorporation. However, the release of Zn2+ ions inhibited the mineralization process when immersed in simulated body fluid. In vitro assays showed significantly highe r values of viability and expression of early markers of celldifferentiation and angiogenesis in a ZnO-content-dependent manner. The next step was to study the osteogenic potential in a sheep bone defect model. Despite their excellent textural properties and cellular response in vitro, the ZnO MBGs were not able to integrate into the bone tissue, which can be explained in terms of inhibition of the mineralization process caused by Zn2+ ions. This work highlights the need to develop nanostructured materials for bone regeneration that can mineralize to interact with bone tissue and induce the processes of implant acceptance, cell colonization by osteogenic cells, and regeneration of lost bone tissue.
PB MDPI
SN 1422-0067
YR 2022
FD 2022-11-11
LK https://hdl.handle.net/20.500.14352/72664
UL https://hdl.handle.net/20.500.14352/72664
LA eng
NO RESEARCH ID B-5081-2017  (Daniel Lozano Borregón)ORCID 0000-0001-5902-9201 (Daniel Lozano Borregón)RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)
NO Unión Europea. Horizonte 2020
NO Ministerio de Ciencia e Innovación (MICINN)
NO Ministerio de Economía y Competitividad (MINECO)
DS Docta Complutense
RD 5 abr 2025