RT Journal Article
T1 The complex biology of FOXO
A1 Monsalve, M.
A1 Olmos Buchelt, Yolanda
AB FOXO transcription factors control proliferation, apoptosis, differentiation and metabolic processes. Loss of FOXO function has been identified in several human cancers, and results in increased cellular survival and a predisposition to neoplasia, especially in epithelial cancer. FOXO factors are therefore bona fide tumor suppressors, and their potential use as therapeutic targets in cancer has been a matter of debate. Importantly, FOXO factors can also positively regulate cell survival through the activation of several detoxification genes, complicating its putative therapeutic potential. Targeting of FOXO factors has also been proposed for the treatment of metabolic dysfunctions such as diabetes mellitus, immunological disorders and neurodegeneration, as well as for the prevention of aging by maintaining the hematopoyetic stem cells niche. But again, data has accumulated that cautions against the potential use of the FOXO activators in these settings. Therefore, greater understanding of the regulation of FOXO target specificity is still needed to boost its use as a therapeutic target. The four members of the FOXO family (FOXO1, FOXO3A, FOXO4 and FOXO6) have distinct but overlapping cellular functions, although they seem to bind a common set of DNA sites. This fact together with the observation that FOXOs are only partially dependent on their DNA binding activity to regulate their target genes highlights the fact that the interaction of the FOXOs with other transcription factors is crucial for the FOXO-mediated transcriptional programs. In this review, we provide an overview of recent progress in the understanding of the modulation of FOXO activity and target specificity by transcription factors and coactivators.
PB Bentham Science Publishers
SN 1389-4501
YR 2011
FD 2011-08
LK https://hdl.handle.net/20.500.14352/105320
UL https://hdl.handle.net/20.500.14352/105320
LA eng
NO Harrison, N. J., Connolly, E., Gascón Gubieda, A., Yang, Z., Altenhein, B., Losada Perez, M., Moreira, M., Sun, J., & Hidalgo, A. (2021). Regenerative neurogenic response from glia requires insulin-driven neuron-glia communication. eLife, 10, e58756. https://doi.org/10.7554/eLife.58756
NO Ministerio de Ciencia e Innovación
NO Ministerio de Sanidad y Consumo
NO Fundación Pro CNIC
DS Docta Complutense
RD 24 abr 2025