RT Journal Article
T1 Mechanisms of Muscle Weakness Associated with Bone Metastases
A1 Mohammad, Khalid S.
A1 Guise, Theresa A.
A1 Manzano García, Miguel
A1 Vallet Regí, María Dulce Nombre
AB Cancer-associated muscle dysfunction represents a deadly clinical problem, with ca. 80% mortality together with an increased toxicity from cancer treatment.. The normal bone remodeling might be disrupted by tumor cells that metastasize to bone in certain stages of cancer, which results in increased morbidity including muscle weakness. The reason for that muscle weakness might be attributed to the reduction on muscle mass or the reduction of muscle function. In fact, it has been demonstrated that in advanced cancers, it is probably caused by a combination of reductions, quantity and quality of muscle. This review focuses on the mechanisms that bone metastases promote skeletal muscle weakness.
PB Ommega publishers
SN 2377-0902
YR 2017
FD 2017-01-27
LK https://hdl.handle.net/20.500.14352/17671
UL https://hdl.handle.net/20.500.14352/17671
LA eng
NO RESEARCHER ID K-3719-2014(Miguel Manzano García)ORCID 0000-0001-6238-6111(Miguel Manzano García)RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)
NO Unión Europea. H2020
NO Ministerio de Economía y Competitividad (MINECO)
NO Ramón Areces Foundation
DS Docta Complutense
RD 21 abr 2025