RT Journal Article
T1 Secondary hyperparathyroidism prevalence and profile, between diabetic and non-diabetic patients with stage 3 to 4 chronic kidney disease attended in internal medicine wards. MiPTH study
A1 Arévalo-Lorido, José Carlos
A1 Carretero Gómez, Juana
A1 García Sánchez, Francisco Javier
A1 Maciá Botejara, Enrique
A1 Ramiro Lozano, José Manuel
A1 Masero Carretero, Antonio
A1 Roberto Robles, Nicolás
A1 Bureo Dacal, Juan Carlos
AB AimsSecondary hyperparathyroidism (SHPTH) is a leading cause of renal osteodystrophy, and an independent risk factor for all-cause and cardiovascular mortality. Our aim is to establish differences in prevalence and profile of SHPTH, regarding diabetics or non-diabetics with chronic kidney disease (CKD).MethodsCross-sectional multicenter study which included patients with stages 3 to 4 CKD. SHPTH was considered when the intact PTH levels (iPTH) were equal or higher than 70 pg/ml. We divided the sample into two groups (diabetics and non-diabetics). We used robust statistical methods.Results409 patients (214 diabetics) were studied. HPTH was found in 60.4% of diabetics vs 65% of non-diabetics (P = 0.42). Diabetics with HPTH were younger (79.5 vs 82.3 years-old, P = 0.005), and had more hypertension (P = 0.0014), dyslipidemia (P = 0.0001) and comorbidities. In multivariate analysis, we found a significant relationship in case of diabetics, with age (OR: 1.04, 95%CI 1.005–1.09 P = 0.02 ), and with statins treatment (OR 2.3, 95%CI 1.17–4.54, P = 0.01).DiscussionThe prevalence of SHPTH between the groups was similar, however, diabetics had more presence of hypertension and dyslipidemia, and SHPTH in this case was also related with moderate microalbuminuria and lower levels of vitamin D. An association with statins was also found in this group.
PB Elsevier
SN 1871-4021
YR 2016
FD 2016-04-15
LK https://hdl.handle.net/20.500.14352/122283
UL https://hdl.handle.net/20.500.14352/122283
LA spa
NO Arévalo-Lorido, J. C., Carretero-Gómez, J., García-Sánchez, F., Maciá-Botejara, E., Ramiro-Lozano, J. M., Masero-Carretero, A., Robles, N. R., & Bureo-Dacal, J. C. (2016). Secondary hyperparathyroidism prevalence and profile, between diabetic and non-diabetic patients with stage 3 to 4 chronic kidney disease attended in internal medicine wards. MiPTH study. Diabetes & metabolic syndrome, 10(2 Suppl 1), S16–S21. https://doi.org/10.1016/j.dsx.2016.01.011
DS Docta Complutense
RD 12 jul 2025