RT Journal Article
T1 Sea Anemones, actinoporins, and cholesterol
A1 Palacios Ortega, Juan
A1 Heras Márquez, Diego
A1 Amigot Sánchez, Rafael
A1 García Montoya, Carmen
A1 Torrijos, Carlos
A1 Laxalde, Diego
A1 Gavilanes, José G.
A1 García Linares, Sara
A1 Martínez Del Pozo, Álvaro
AB Spanish or Spanish-speaking scientists represent a remarkably populated group within the scientific community studying pore-forming proteins. Some of these scientists, ourselves included, focus on the study of actinoporins, a fascinating group of metamorphic pore-forming proteins produced within the venom of several sea anemones. These toxic proteins can spontaneously transit from a water-soluble fold to an integral membrane ensemble because they specifically recognize sphingomyelin in the membrane. Once they bind to the bilayer, they subsequently oligomerize into a pore that triggers cell-death by osmotic shock. In addition to sphingomyelin, some actinoporins are especially sensible to some other membrane components such as cholesterol. Our group from Universidad Complutense of Madrid has focused greatly on the role played by sterols in this water-membrane transition, a question which still remains only partially solved and constitutes the main core of the article below.
YR 2022
FD 2022-08-07
LK https://hdl.handle.net/20.500.14352/112225
UL https://hdl.handle.net/20.500.14352/112225
LA eng
NO Palacios-Ortega J, Heras-Márquez D, Amigot-Sánchez R, García-Montoya C, Torrijos C, Laxalde D, Gavilanes JG, García-Linares S, Martínez-Del-Pozo Á. Sea Anemones, Actinoporins, and Cholesterol. Int J Mol Sci. 2022 Aug 7;23(15):8771. doi: 10.3390/ijms23158771. PMID: 35955905; PMCID: PMC9369217.
NO Banco Santander
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 6 abr 2025