RT Journal Article
T1 Th17 polarization of memory Th cells in early arthritis: the vasoactive intestinal peptide effect
A1 Jimeno, Rebeca
A1 Leceta Martínez, Javier
A1 Garín, Marina I.
A1 Ortiz, Ana M.
A1 Mellado, Mario
A1 Rodríguez Frade, José Miguel
A1 Martínez Mora, María Del Carmen
A1 Pérez García, Selene
A1 Pérez Gomáriz, Rosa María
A1 Juarranz Moratilla, Yasmina
AB Several studies in humans indicate the implication of Th17 cells in RA. Therapies targeting their pathogenicity, as well as their plasticity to the Th17/1 phenotype, could ameliorate the progression of the pathology. The neuroendocrine environment has a major impact on the differentiation of lymphoid cells. VIP is present in the microenvironment of the joint, and its known therapeutic  effects are supported by several studies on RA. We examine the ability of VIP to modulate the differentiation of Th17 cells. Peripheral blood CD4+CD45RO+ T cells from HD and eRA patients were expanded under Th17-polarizing conditions in the presence of TGF-b. After 7 days, the higher IL-17A, IL-21, and IL-9 levels and lower IL-22 levels indicate the nonpathogenic profile for Th17 cells in HD. In contrast, Th17 cells from eRA patients produced significantly more IL-22 and IFN-g, and these cells show a more Th17/1 profile, indicating a pathogenic phenotype. Interestingly, when VIP was present in the Th17 conditioned medium, increased levels of IL-10 and IL-9 were detected in HD and eRA patients. VIP also reduced the levels of IL-22 in eRA patients. These data suggest that VIP reduces the pathogenic profile of the Th17-polarized cells. This effect was accompanied by an increased in the Treg/Th17 profile, as shown by the increase levels of Foxp3. In conclusion, this report addresses a novel and interesting question on the effect of VIP on human Th17 cells and adds clinical relevance by analyzing, in parallel, HD and eRA patients. J. Leukoc. Biol. 98: 000–000; 2015.
PB The Society for Leukocyte Biology.
SN 0741-5400
YR 2015
FD 2015-08
LK https://hdl.handle.net/20.500.14352/23188
UL https://hdl.handle.net/20.500.14352/23188
LA eng
NO Jimeno, R., Leceta Martínez, J., Garín, M. I. et al. «Th17 Polarization of Memory Th Cells in Early Arthritis: The Vasoactive Intestinal Peptide Effect». Journal of Leukocyte Biology, vol. 98, n.o 2, agosto de 2015, pp. 257-69. Crossref, https://doi.org/10.1189/jlb.3a0714-327r.
NO Comunidad de Madrid
NO Institudo de Salud Carlos III: Fondo de Investigación Sanitaria
DS Docta Complutense
RD 25 dic 2025