RT Journal Article
T1 Loneliness, depression and genetics in elderly, pronostic factors of a worse health condition?
A1 Delgado Losada, María Luisa
A1 Bouhaben, Jaime
A1 Arroyo Pardo, Eduardo
A1 Aparicio Vizuete, Aranzazu
A1 López Parra, Ana María
AB Loneliness is considered a prognostic factor for poorer health status in the elderly. It is proposed to analyze the role of loneliness in health status in terms of various factors. A total of 1747 individuals from the pilot survey of the Aging in Spain Longitudinal Study (ELES-PS) were reviewed. ELES is a cross-sectional study for collecting health variables, food habits, socioeconomic data, and cognitive and functional capacities, which was carried out on a Spanish representative sample of noninstitutionalized persons of 50 years of age or older. Moreover, since telomere shortening is associated with cellular senescence, 35 telomere-related SNPs and cognitive impairments were analyzed. The results characterize the “solos” as males of 50–60 years, who were overweight and had lower levels of hemoglobin and neutrophils. There is also an association between five SNPs related to telomere length and BDNF. A group of people with loneliness and depression was identified with poorer health and cognitive status, poorer perception of their quality of life, poorer quality of sleep, and lower physical activity. Therefore, it follows that telomeres and BDNF play a role as intermediaries between loneliness and depression and their relationship with a worse state of health.
PB MDPI
SN 1660-4601
YR 2022
FD 2022-11-16
LK https://hdl.handle.net/20.500.14352/93109
UL https://hdl.handle.net/20.500.14352/93109
LA eng
NO Delgado Losada M.S.; Bouhaben J.; Arroyo Pardo E.; Aparicio Vizuete A.;López-Parra A.M. Loneliness, depression and genetics in elderly, pronostic factors of a worse health condition?. Int J Environ Res Public Health. 2022 Nov 22;19(23):15456. doi: 10.3390/ijerph192315456. PMID: 36497531; PMCID: PMC9739711.
NO UCM-SANTANDER
DS Docta Complutense
RD 11 abr 2025