RT Journal Article
T1 How to make C-N bonds using boronic acids and their derivatives without transition metals
T2 Cómo hacer enlaces C-N usando ácidos borónicos y sus derivados sin usar metales de transición
A1 García Csaky, Aurelio
A1 Roscales García, Silvia
AB This tutorial review describes recent developments in carbon–nitrogen bond-forming reactions (amination, amidation, nitration and nitrosation) that involve the use of boronic acids and some of their derivatives as carbon-nucleophiles in the absence of transition-metals. Issues pertaining to reagents andmechanisms are discussed.
PB Royal Society of Chemistry
YR 2020
FD 2020-07
LK https://hdl.handle.net/20.500.14352/113549
UL https://hdl.handle.net/20.500.14352/113549
LA eng
NO Chem. Soc. Rev., 2020,49, 5159-5177
NO Key learning points(1) Formation of tetrahedral boronates induces a nucleophilic activation of the carbon backbone of boronic acids and their derivatives (boronic acids, boronateesters, or potassium organotrifluoroborates).(2) N–B coordination of a variety of N-LG reagents (LG = Leaving Group) followed by 1,2-C(B–N)-shift triggers C–N bond formation in the absence of transitionmetals.(3) Deoxygenation of nitro and nitroso groups turns them into useful nitrogen electrophiles for amine formation.(4) Acylboron compounds react with N-LG reagents (LG = leaving group) through their carbonyl group to form hemiaminals that evolve to amides.
NO Ministerio de Ciencia, Innovacio´n y Universidades
DS Docta Complutense
RD 27 abr 2025