RT Journal Article
T1 Phagocytic Integrins: Activation and Signaling
A1 Torres Gómez, Álvaro
A1 Cabañas Gutiérrez, Carlos
A1 Lafuente Duarte, María Esther
AB Phagocytic integrins are endowed with the ability to engulf and dispose of particles of different natures. Evolutionarily conserved from worms to humans, they are involved in pathogen elimination and apoptotic and tumoral cell clearance. Research in the field of integrin-mediated phagocytosis has shed light on the molecular events controlling integrin activation and their effector functions. However, there are still some aspects of the regulation of the phagocytic process that need to be clarified. Here, we have revised the molecular events controlling phagocytic integrin activation and the downstream signaling driving particle engulfment, and we have focused particularly on αMβ2/CR3, αXβ2/CR4, and a brief mention of αVβ5/αVβ3integrins.
PB Frontiers
SN 1664-3224
YR 2020
FD 2020-04-30
LK https://hdl.handle.net/20.500.14352/116145
UL https://hdl.handle.net/20.500.14352/116145
LA eng
NO Torres-Gomez, A., Cabañas, C., & Lafuente, E. M. (2020). Phagocytic Integrins: Activation and Signaling. Frontiers in immunology, 11, 738. https://doi.org/10.3389/fimmu.2020.00738
NO Ministerio Español de Economı́a y Competitividad (España)
DS Docta Complutense
RD 8 abr 2025