RT Journal Article
T1 A new role for erythropoietin in the homeostasis of red blood cells
A1 Arias, Clemente F.
A1 Valente Leal, Nuno
A1 Bertocchini, Federica
A1 Marques, Sofía
A1 Acosta, Francisco J.
A1 Fernández Arias, Cristina
AB The regulation of red blood cell (RBC) homeostasis is widely assumed to rely on the control of cell production by erythropoietin (EPO) and the destruction of cells at a fixed, species-specific age. In this work, we show that such a regulatory mechanism would be a poor homeostatic solution to satisfy the changing needs of the body. Effective homeostatic control would require RBC lifespan to be variable and tightly regulated. We suggest that EPO may control RBC lifespan by determining CD47 expression in newly formed RBCs and SIRP-α expression in sinusoidal macrophages. EPO could also regulate the initiation and intensity of anti-RBC autoimmune responses that curtail RBC lifespan in some circumstances. These mechanisms would continuously modulate the rate of RBC destruction depending on oxygen availability. The control of RBC lifespan by EPO and autoimmunity emerges as a key mechanism in the homeostasis of RBCs.
PB Springer Nature
SN 2399-3642
YR 2024
FD 2024-06-01
LK https://hdl.handle.net/20.500.14352/113661
UL https://hdl.handle.net/20.500.14352/113661
LA eng
NO Arias, C.F., Valente-Leal, N., Bertocchini, F. et al. A new role for erythropoietin in the homeostasis of red blood cells. Commun Biol 7, 58 (2024). https://doi.org/10.1038/s42003-023-05758-2
DS Docta Complutense
RD 8 abr 2025