RT Journal Article
T1 Changes of CD3+CD56+ γδ T cell number and apoptosis during hospital admission are related to mortality in septic patients
A1 Andreu-Ballester, J.C.
A1 Arribas, M.A.
A1 Rico, M.
A1 García-Ballesteros, C.
A1 Galindo-Regal, L.
A1 Sorando-Serra, R.
A1 Albert, L.
A1 Navarro, A.
A1 López-Chuliá, F.
A1 Peydró, F.
A1 Cuéllar Del Hoyo, María Del Carmen
AB Immunoparalysis and apoptosis of T cells are serious problems for the evolution of septic patients. We aimed to relate changes in the number of αβ and γδ T cells during hospital stay to the poor evolution of sepsis. In this prospective study, we recruited a total of 92 septic patients from the Emergency and Intensive Care Departments of two Hospitals, according to the latest criteria for the definition and management of sepsis. According to the severity of the septic process, there was a progressive decrease in T cells, being much more intense in γδ T cells. This decrease recovered in surviving patients, but CD3+CD56+ γδ T cells continued to decreased during hospital stay in non-surviving patients. Apoptosis increased in sepsis. Cell death of CD3+CD56+ γδ T cells progressively increased according to the severity of sepsis, especially in non-surviving patients.
PB Elsevier
SN 1521-6616
YR 2022
FD 2022-02-14
LK https://hdl.handle.net/20.500.14352/101872
UL https://hdl.handle.net/20.500.14352/101872
LA eng
NO Andreu-Ballester JC, Arribas MA, Rico M, García-Ballesteros C, Galindo-Regal L, Sorando-Serra R, Albert L, Navarro A, López-Chuliá F, Peydró F, Cuéllar C. Changes of CD3+CD56+ γδ T cell number and apoptosis during hospital admission are related to mortality in septic patients. Clin Immunol. 2022 Mar;236:108956. doi: 10.1016/j.clim.2022.108956. Epub 2022 Feb 14. PMID: 35176483.
DS Docta Complutense
RD 4 ago 2024