RT Journal Article
T1 Cognitive dysfunction associated with COVID-19: a comprehensive neuropsychological study
A1 Delgado-Alonso, Cristina
A1 Valles-Salgado, Maria
A1 Delgado Álvarez, Alfonso
A1 Yus, Miguel
A1 Gómez-Ruiz, Natividad
A1 Jorquera, Manuela
A1 Polidura, Carmen
A1 Gil, María José
A1 Marcos Dolado, Alberto
A1 Matías-Guiu Guía, Jorge
A1 Matías-Guiu, Jordi A.
AB ObjectiveRecent evidence suggests that patients suffering post-acute COVID syndrome frequently report cognitive complaints, but their characteristics and pathophysiology are unknown. This study aims to determine the characteristics of cognitive dysfunction in patients reporting cognitive complaints after COVID-19 and to evaluate the correlation between cognitive function and anxiety, depression, sleep, and olfactory function.MethodsCross-sectional study involving 50 patients with COVID-19 reporting cognitive complaints 9.12 ± 3.46 months after the acute infection. Patients were evaluated with a comprehensive neuropsychological protocol, and scales of fatigue, depression, anxiety, sleep and an olfactory test. Normative data and an age- and education matched healthy control group were used for comparison.ResultsCOVID-19 patients showed a diminished performance on several tests evaluating attention and executive function, with alterations in processing speed, divided attention, selective attention, visual vigilance, intrinsic alertness, working memory, and inhibition; episodic memory; and visuospatial processing. Cognitive performance was correlated with olfactory dysfunction, and sleep quality and anxiety to a lesser extent, but not depression.ConclusionsPatients with COVID-19 reporting cognitive symptoms showed a reduced cognitive performance, especially in the attention-concentration and executive functioning, episodic memory, and visuospatial processing domains. Future studies are necessary to disentangle the specific mechanisms associated with COVID-19 cognitive dysfunction.
PB Elsevier
SN 0022-3956
YR 2022
FD 2022
LK https://hdl.handle.net/20.500.14352/100253
UL https://hdl.handle.net/20.500.14352/100253
LA eng
NO Cristina Delgado-Alonso, Maria Valles-Salgado, Alfonso Delgado-Álvarez, Miguel Yus, Natividad Gómez-Ruiz, Manuela Jorquera, Carmen Polidura, María José Gil, Alberto Marcos, Jorge Matías-Guiu, Jordi A. Matías-Guiu, Cognitive dysfunction associated with COVID-19: A comprehensive neuropsychological study, Journal of Psychiatric Research, Volume 150, 2022, Pages 40-46, ISSN 0022-3956, https://doi.org/10.1016/j.jpsychires.2022.03.033
DS Docta Complutense
RD 22 may 2025