RT Journal Article
T1 Melatonin: a multitasking indoleamine to modulate hippocampal neurogenesis
A1 Romero Martínez, Manuel Alejandro
A1 Morales García, José Ángel
A1 Ramos Alonso, Eva
AB Neurodegeneration affects a large number of cell types including neurons, astrocytes or oligodendrocytes, and neural stem cells. Neural stem cells can generate new neuronal populations through proliferation, migration, and differentiation. This neurogenic potential may be a relevant factor to fight neurodegeneration and aging. In the last years, we can find growing evidence suggesting that melatonin may be a potential modulator of adult hippocampal neurogenesis. The lack of therapeutic strategies targeting neurogenesis led researchers to explore new molecules. Numerous preclinical studies with melatonin observed how melatonin can modulate and enhance molecular and signaling pathways involved in neurogenesis. We made a special focus on the connection between these modulation mechanisms and their implication in neurodegeneration, to summarize the current knowledge and highlight the therapeutic potential of melatonin.
PB Wolters Kluwer
SN 1673-5374
YR 2022
FD 2022-08-02
LK https://hdl.handle.net/20.500.14352/116950
UL https://hdl.handle.net/20.500.14352/116950
LA eng
NO Romero A, Morales-García JA, Ramos E (2023) Melatonin: a multitasking indoleamine to modulate hippocampal neurogenesis. Neural Regen Res 18(3): 503-505. DOI: https://doi.org/10.4103/1673-5374.350189
NO Author contributions:All authors listed have made a substantial, direct, and intellectual contribution to the work and approved it for publication. AR conceived the idea and he has made substantial contributions to conception, design, supervision. ER and JAMG wrote-original draft preparation and critically revised the manuscript. All co-authors read and approved the final version of the manuscript.
DS Docta Complutense
RD 9 abr 2025