RT Journal Article
T1 Design of thermoresponsive polymeric gates with opposite controlled release behaviors
A1 Guisasola, Eduardo
A1 Baeza, Alejandro
A1 Talelli, Marina
A1 Arcos Navarrete, Daniel
A1 Vallet Regí, María Dulce Nombre
AB Stimuli-responsive devices are novel tools widely studied in the nanomedicine research field. In this work, magnetic-responsive mesoporous silica nanoparticles (MMSNs) were coated with an engineered thermoresponsive co-polymer. Magnetic cores are used as heating sources when they are exposed to an alternating magnetic field. The polymer structure suffers a change from hydrophilic to hydrophobic state when the temperature is raised above the lower critical solution temperature (LCST) or volume phase transition temperature (VPTT), acting as a gate-keeper of a model drug trapped inside the silica matrix. Fluorescein departure can be tuned employing two different polymer structures on the silica surface which exhibit the same transition temperature (42 degrees C) but a different grafting density: one of them being a dense crosslinked polymer network and the other one a hairy linear polymer layer. The release profile reveals to be the opposite between these two different coatings, allowing suitable drug release behavior for different clinical situations.
PB Royal Society of Chemistry
SN 2046-2069
YR 2016
FD 2016-04-25
LK https://hdl.handle.net/20.500.14352/23169
UL https://hdl.handle.net/20.500.14352/23169
LA eng
NO ORCID 0000-0002-9042-8865 (Alejandro Baeza)RESEARCHER ID K-8193-2014 (Alejandro Baeza)ORCID 0000-0002-2549-1745 (Eduardo Guisasola Cal)RESEARCHER ID E-8300-2012 (Eduardo Guisasola Cal)RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)
NO Ministerio de Economía y Competitividad (MINECO)
NO Agening Network Excellence
NO Iniciativa Ingenio
NO Instituto de Salud Carlos III
NO CIBER-BBN
DS Docta Complutense
RD 29 abr 2024