RT Journal Article
T1 Effects of Weight Loss after Bariatric Surgery for Morbid Obesity on Vascular Endothelial Growth Factor-A, Adipocytokines, and Insulin
A1 García de la Torre, Nuria
A1 Aparicio, Eugenio
A1 Puente, Monserrat
A1 Aniceto L. Charro, 
A1 Rubio Herrera, Miguel Ángel
A1 Bordiú Obonza, María Elena
A1 Cabrerizo García, Lucio
A1 Hernández Pérez, María Carmen
A1 Sánchez Pernaute, Andrés
A1 Díez Valladares, Luis Ignacio
A1 Torres García, Antonio José
A1 Charro Salgado, Aniceto
AB Background: Adipocytes regulate blood vessel formation, and in turn endothelial cells promote preadipocyte differentiation through the expression of proangiogenic factors, such as vascular endothelial growth factor (VEGF)-A. Some adipocytokines and hormones also have an effect on vascular development.Objectives: Our objectives were to analyze the relationship between weight and circulating VEGF-A in morbidly obese subjects before and after bariatric surgery, and investigate the relationship between circulating VEGF-A and certain adipocytokines and hormones regulating adipocytes.Methods: A total of 45 morbidly obese women and nine lean females were included in the study. Patients underwent bariatric surgery: vertical banded gastroplasty (n = 17), gastric bypass (n = 17), and biliopancreatic diversion (n = 11). Serum samples for VEGF-A, adiponectin, leptin, ghrelin, and insulin were obtained preoperatively and 9-12 months after surgery.Results: Obese patients showed significantly higher VEGF-A levels than controls (306.3 +/- 170.3 vs. 187.6 +/- 91.9 pg/ml; P = 0.04), decreasing to 246.1 +/- 160.4 after surgery (P < 0.001), with no differences among surgical procedures. In controls there was an inverse correlation between VEGF-A and ghrelin (r = -0.85; P <. 01), but not in obese patients. Leptin and insulin concentrations were increased in obese patients, with a significant decrease shown after weight loss with surgery. Conversely, adiponectin concentrations were lower in obese patients, with a significant increase shown after weight loss with surgery. Ghrelin was higher in controls than obese patients, decreasing after gastric bypass and biliopancreatic diversion, but not after vertical banded gastroplasty.Conclusion: Serum VEGF-A levels are significantly higher in obese patients than in lean controls, decreasing after weight loss with bariatric surgery, behaving similarly to other hormones related to adipose mass like leptin and insulin. (J Clin Endocrinol Metab 93: 4276-4281, 2008
PB Endocrine Society
SN 0021-972X
YR 2008
FD 2008-11-01
LK https://hdl.handle.net/20.500.14352/116248
UL https://hdl.handle.net/20.500.14352/116248
LA eng
NO García de la Torre N, Rubio MA, Bordiú E, Cabrerizo L, Aparicio E, Hernández C, Sánchez-Pernaute A, Díez-Valladares L, Torres AJ, Puente M, Charro AL. Effects of weight loss after bariatric surgery for morbid obesity on vascular endothelial growth factor-A, adipocytokines, and insulin. J Clin Endocrinol Metab. 2008 Nov;93(11):4276-81. doi: 10.1210/jc.2007-1370. Epub 2008 Aug 19. PMID: 18713823.
DS Docta Complutense
RD 8 abr 2025