RT Journal Article
T1 Liver Upregulation of Genes Involved in Cortisol Production and Action Is Associated with Metabolic Syndrome in Morbidly Obese Patients
A1 Torrecilla, Esther
A1 Fernández-Vázquez, Gumersindo
A1 Vicent, David
A1 Sánchez-Franco, Franco
A1 Barabash Bustelo, Ana
A1 Cabrerizo García, Lucio
A1 Sánchez Pernaute, Andrés
A1 Torres García, Antonio José
A1 Rubio Herrera, Miguel Ángel
AB Hepatic 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) activity, which converts cortisone (inactive) to cortisol, is downregulated in obesity. However, this compensation fails in obese with metabolic abnormalities, such as diabetes. To further characterize the tissue-specific cortisol regeneration in obesity, we have investigated the mRNA expression of genes related to local cortisol production, i.e., 11 beta-HSD1, hexose-6-phosphate dehydrogenase (H6PDH) and cortisol action, glucocorticoid receptor (GR) and a cortisol target gene, phosphoenolpyruvate carboxykinase (PEPCK) in the liver, and visceral (VAT) and subcutaneous (SAT) adipose tissues from morbidly obese patients with and without metabolic syndrome (MS).Fifty morbidly obese patients undergoing bariatric surgery, 14 men (mean age, 41.3 +/- 3.5 years; BMI, 48.0 +/- 3.6 kg/m(2)) and 36 women (mean age, 44.6 +/- 1.9 years; BMI, 44.9 +/- 1.2 kg/m(2)), were classified as having MS (MS+, n = 20) or not (MS-, n = 30). Tissue mRNA levels were measured by real-time polymerase chain reaction.Hepatic mRNA levels of these genes were higher in obese patients with MS (11 beta-HSD1, P = 0.002; H6PDH, P = 0.043; GR, P = 0.033; PEPCK, P = 0.032) and positively correlated with the number of clinical characteristics that define the MS. The expression of the four genes positively correlated among them. In contrast to the liver, these genes were not differently expressed in VAT or SAT, when MS+ and MS- obese patients were compared.Coordinated liver-specific upregulation of genes involved in local cortisol regeneration and action support the concept that local hepatic hypercortisolism contributes to development of MS in morbidly obese patients.
PB Springer
SN 0960-8923
YR 2011
FD 2011-10-04
LK https://hdl.handle.net/20.500.14352/116205
UL https://hdl.handle.net/20.500.14352/116205
LA eng
NO Torrecilla E, Fernández-Vázquez G, Vicent D, Sánchez-Franco F, Barabash A, Cabrerizo L, Sánchez-Pernaute A, Torres AJ, Rubio MA. Liver upregulation of genes involved in cortisol production and action is associated with metabolic syndrome in morbidly obese patients. Obes Surg. 2012 Mar;22(3):478-86. doi: 10.1007/s11695-011-0524-9. PMID: 21964795.
DS Docta Complutense
RD 18 abr 2025