RT Journal Article
T1 P300 Wave Alterations and Cognitive Impairment in Cerebellum Lesions
A1 Nanda, Sourav
A1 Lapeña Motilva, José
A1 Kumar Misra, Amar
A1 Guha, Gautam
A1 Ghosh, Sinjan
A1 Manna, Akash
A1 Roy, Soumit
A1 Benito León, Julián
AB <jats:title>Abstract</jats:title><jats:p>Patients with cognitive deficits have a prolonged latency and reduced amplitude of the P300 wave. However, no study has correlated P300 wave alterations with the cognitive performance of patients with cerebellar lesions. We aimed to determine if the cognitive status of these patients was associated with P300 wave alterations. We recruited 30 patients with cerebellar lesions from the wards of the N.R.S. Medical College, Kolkata, in West Bengal (India). The Kolkata Cognitive Screening Battery tasks and the Frontal Assessment Battery (FAB) were used to assess the cognitive status and the International Cooperative Ataxia Rating Scale (ICARS) for cerebellar signs. We compared the results with the normative data of the Indian population. Patients had P300 wave alterations with a significant increase in latency and a non-significant trend in amplitude. In a multivariate model, P300 wave latency was positively associated with the ICARS kinetic subscale (<jats:italic>p</jats:italic> = 0.005) and age (<jats:italic>p</jats:italic> = 0.009), regardless of sex and years of education. In the model that included cognitive variables, P300 wave latency was negatively associated with performance in phonemic fluency (<jats:italic>p</jats:italic> = 0.035) and construction (<jats:italic>p</jats:italic> = 0.009). Furthermore, P300 wave amplitude was positively associated with the FAB total score (<jats:italic>p</jats:italic> &lt; 0.001). In closing, patients with cerebellar lesions had an increase in latency and a decrease in the amplitude of the P300 wave. These P300 wave alterations were also associated with worse cognitive performance and some of the subscales of the ICARS, reinforcing that the cerebellum has motor, cognitive, and affective functions.</jats:p>
PB SpringerLink
SN 1473-4230
YR 2023
FD 2023-05-26
LK https://hdl.handle.net/20.500.14352/103360
UL https://hdl.handle.net/20.500.14352/103360
LA eng
NO Nanda S, Lapeña-Motilva J, Misra AK, Guha G, Ghosh S, Manna A, Roy S, Benito-León J. P300 Wave Alterations and Cognitive Impairment in Cerebellum Lesions. Cerebellum. 2023 May 26. doi: 10.1007/s12311-023-01570-0. Epub ahead of print. PMID: 37233909.
NO National Institutes of Health (EEUU)
NO European Commission
NO Ministerio de Ecnomía y Competitividad
NO Fundación Española para la Ciencia y la Tecnología
DS Docta Complutense
RD 25 abr 2025