RT Journal Article
T1 Anti-melanogenic and Anti-inflammatory Activities of Hibiscus sabdariffa
A1 Apaza Ticona, Luis Nestor
A1 Pérez Uz, María Blanca
A1 García Esteban, María Teresa
A1 Aguilar Rico, Francisco
A1 Slowing Barillas, Karla Verónica
AB Hibiscus sabdariffa L., Malvaceae, is traditionally cultivated for its stem, leaves, calyces, and seeds as all parts have industrial, medicinal, and cosmetic applications. Likewise, there are many works on the biological properties of the aqueous extract of H. sabdariffa due to its high content of polyphenolic compounds. Using the Folin-Ciocalteu method, the total polyphenol content of an aqueous extract of a sample from Guatemala was found to be 15.97 ± 0.49 mg GAE/g. The presence of ten phenolic acids, ten flavonoids, and two anthocyanins was determined by 1 H NMR analysis. The anti-melanogenic activity assay of the aqueous extract showed inhibition of the tyrosinase activity (IC50 3.53 ± 0.16 μg/ml) and inhibition of the melanin production (IC50 3.90 ± 0.17 μg/ml) in the B16F10 cell line. Finally, the aqueous extract showed an inhibition of NO production with an IC50 of 4.72 ± 0.34 μg/ml and 3.62 ± 0.36 μg/ml in the RAW 264.7 and B16F10 cell lines, respectively. Our results allowed us to identify those polyphenolic compounds present in the aqueous extract of H. sabdariffa whose synergic effect increases the anti-melanogenic and anti-inflammatory properties of the aqueous extract.
PB Springer
YR 2022
FD 2022-02-09
LK https://hdl.handle.net/20.500.14352/71791
UL https://hdl.handle.net/20.500.14352/71791
LA eng
NO Apaza Ticona, L. N., Pérez Uz, M. B., García Esteban, M. T. et al. «Anti-Melanogenic and Anti-Inflammatory Activities of Hibiscus Sabdariffa». Revista Brasileira de Farmacognosia, vol. 32, n.o 1, febrero de 2022, pp. 127-32. DOI.org (Crossref), https://doi.org/10.1007/s43450-022-00236-y.
NO Fundación de la Universidad Autónoma de Madrid
DS Docta Complutense
RD 3 abr 2025