RT Journal Article
T1 Social environment as a modulator of immunosenescence
A1 Garrido Tarrio, Antonio
A1 Martínez de Toda Cabeza, Irene
A1 Díaz del Cerro, Estefanía
A1 Félix, Judith
A1 Ceprián, Noemí
A1 González Sánchez, M.
A1 Fuente del Rey, Mónica de la
AB Immune system aging, a process known as immunosenescence, involves a striking rearrangement affecting all immune cells, resulting in an increased rate of infections and a major incidence of autoimmune diseases and cancer. Nonetheless, differences in how individuals of the same chronological age carry out this immunosenescence establishment and thus the aging rate have been reported. In the context of neuroimmunoendocrine communication and its role in the response to stress situations, growing evidence suggests that social environments profoundly influence all physiological responses, especially those linked to immunity. Accordingly, negative contexts (loneliness in humans/social isolation in rodents) were associated with immune impairments and decreased lifespan. However, positive social environments have been correlated with adequate immunity and increased lifespan. Therefore, the social context in which an individual lives is proposed as a decisive modulator of the immunosenescence process and, consequently, of the rate of aging. In this review, the most important findings regarding how different social environments (negative and positive) modulate immunosenescence and therefore the aging rate, as well as the role of stress responses, hormesis, and resilience in these environments will be explained. Finally, several possible molecular mechanisms underlying the effects of negative and positive environments on immunosenescence will be suggested.
PB Cambridge University Press
SN Electronic: 1462-3994
YR 2022
FD 2022-08-01
LK https://hdl.handle.net/20.500.14352/72538
UL https://hdl.handle.net/20.500.14352/72538
LA eng
NO Universidad Complutense de Madrid (UCM)
DS Docta Complutense
RD 7 may 2024