RT Journal Article
T1 The multilayered complexity of the chemokine receptor system
A1 D’Agostino, Gianluca
A1 García-Cuesta, Eva María
A1 Gomáriz, Rosa P.
A1 Rodríguez-Frade, José Miguel
A1 Mellado, Mario
AB The chemokines receptor family are membrane-expressed class A-specific seven-transmembrane receptors linked to G proteins. Through interaction with the corresponding ligands, the chemokines, they induce a wide variety of cellular responses including cell polarization, movement, immune and inflammatory responses, as well as the prevention of HIV-1 infection. Like a Russian matryoshka doll, the chemokine receptor system is more complex than initially envisaged. This review focuses on the mechanisms that contribute to this dazzling complexity and how they modulate the signaling events triggered by chemokines. The chemokines and their receptors exist as monomers, dimers and oligomers, their expression pattern is highly regulated, and the ligands can bind distinct receptors with similar affinities. The use of novel imaging-based technologies, particularly real-time imaging modalities, has shed new light on the very dynamic conformations that chemokine receptors adopt depending on the cellular context, and that affect chemokine-mediated responses. This complex scenario presents both challenging and exciting opportunities for drug Discovery.
PB Elsevier
SN 0006-291X
YR 2020
FD 2020-03-05
LK https://hdl.handle.net/20.500.14352/7932
UL https://hdl.handle.net/20.500.14352/7932
LA eng
NO Ministerio de Ciencia e Innovación (MICINN)
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 17 abr 2025