%0 Journal Article
%A Delgado Blas, José Francisco
%A Martínez Ovejero, Cristina
%A Abadia Patiño, Lorena
%A González Zorn, Bruno
%T Coexistence of mcr-1 and blaNDM-1 in Escherichia coli from Venezuela
%D 2016
%@ 0066-4804
%U https://hdl.handle.net/20.500.14352/18986
%X We studied the presence of the mobile colistin resistance gene mcr-1 in human, animal, and environmental Enterobacteriaceae samples from Cumana, Venezuela, that were collected in 2015. The mcr-1 gene was detected in 2/93 Escherichia coli isolates from swine (novel ST452) and human (ST19) samples that were resistant to colistin. Whole-genome sequencing and transformation experiments identified mcr-1 on an IncI2 plasmid. One of the isolates also bore the widely spread carbapenemase NDM-1. A One Health approach is necessary to further elucidate the flux of these high-risk genes.
%~